Title:
組み合わせ抗ウイルス療法のための組成物および方法
Document Type and Number:
Japanese Patent JP2006515624
Kind Code:
A
Abstract:
The present invention relates to therapeutic combinations of [2-(6-amino-purin-9-yl)-1-methyl-ethoxymethyl]-phosphonic acid diisopropoxycarbonyloxymethyl ester (tenofovir disoproxil fumarate, Viread®) and (2 R , 5 S , cis)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (emtricitabine, Emtriva¢, (-)-cis FTC) and their physiologically functional derivatives. The combinations may be useful in the treatment of HIV infections, including infections with HIV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors. The present invention is also concerned with pharmaceutical compositions and formulations of said combinations of tenofovir disoproxil fumarate and emtricitabine, and their physiologically functional derivatives, as well as therapeutic methods of use of those compositions and formulations.
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Inventors:
Dar, Terence C.
Menning, Mark M.
Oriya, Reza
Menning, Mark M.
Oriya, Reza
Application Number:
JP2006500943A
Publication Date:
June 01, 2006
Filing Date:
January 13, 2004
Export Citation:
Assignee:
Gilead Sciences, Inc.
International Classes:
A61K31/513; A61K9/20; A61K31/675; A61K31/7076; A61K45/00; A61K45/06; A61K47/02; A61K47/36; A61K47/38; A61P31/12; A61P31/18; A61P43/00; C07D411/04
Foreign References:
| WO2002008241A2 | 2002-01-31 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita