Title:
ネコ科動物における甲状腺機能亢進症を診断および監視する組成物および方法
Document Type and Number:
Japanese Patent JP5930556
Kind Code:
B2
Abstract:
The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of, e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.
Inventors:
Samel Al-Murani
Shanmin Gao
Shanmin Gao
Application Number:
JP2014516005A
Publication Date:
June 08, 2016
Filing Date:
June 14, 2012
Export Citation:
Assignee:
Hills Pet Nutrician Incorporated
International Classes:
C12Q1/68; A23L33/00; A61K45/00; A61P43/00; C12N15/09; C12N15/115; G01N33/53; G01N37/00
Other References:
Thyroid,2005年 2月,Vol.15, No.2,p.114-120
J Vet Intern Med.,2011年 5月 3日,Vol.25, No.3,p.678,ABSTRACT EN-2
Eur J Endocrinol.,2007年 3月 1日,Vol.156, No.3,p.295-301
J Clin Endocrinol Metab.,2009年 4月21日,Vol.94, No.7,p.2602-2609
J Clin Endocrinol Metab.,2004年 2月,Vol.89, No.2,p.930-935
J Vet Intern Med.,2011年 5月 3日,Vol.25, No.3,p.678,ABSTRACT EN-2
Eur J Endocrinol.,2007年 3月 1日,Vol.156, No.3,p.295-301
J Clin Endocrinol Metab.,2009年 4月21日,Vol.94, No.7,p.2602-2609
J Clin Endocrinol Metab.,2004年 2月,Vol.89, No.2,p.930-935
Attorney, Agent or Firm:
Murai Koji