Title:
FGF受容体キナーゼ阻害剤のための組成物および方法
Document Type and Number:
Japanese Patent JP2009537520
Kind Code:
A
Abstract:
Described are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat or prevent disease or disordered associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activity of kinases such as Abl, ALK, AMPK, Aurora, Axl, Bcr-Abl, BIK, Bmx, BRK, BTK, c-Kit, CSK, cSrc, CDK1, CHK2, CK1, CK2, CaMKII, CaMKIV, DYRK2, EGFR, EphB1, FES, FGFR1, FGFR2, FGFR3, Flt1, Flt3, FMS, Fyn, GSK3beta, IGF-1R, IKKalpha, IKKbeta, IR, IRAK4, ITK, JAK2, JAK3, JNK1alpha1, JNK2alpha, KDR, Lck, LYN, MAPK1, MAPKAP-K2, MEK1, MET, MKK4, MKK6, MST2, NEK2, NLK, p70S6K, PAK2, PDGFR, PDGFRalpha, PDK1, Pim-2, Plk3, PKA, PKBalpha, PKCalpha, PKCtheta, PKD2, c-Raf, RET, ROCK-I, ROCK-II, Ron, Ros, Rsk1, SAPK2a, SAPK2b, SAPK3, SAPK4, SGK, SIK, Syk, Tie2, TrkB, WNK3, and ZAP-70.
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Inventors:
Len Pinda
Jang Guobao
You Shuri
Sim Tebo
Nathaniel S. Gray
Youngpin Che
One Shin
Yoon Hee
Jang Guobao
You Shuri
Sim Tebo
Nathaniel S. Gray
Youngpin Che
One Shin
Yoon Hee
Application Number:
JP2009510944A
Publication Date:
October 29, 2009
Filing Date:
April 06, 2007
Export Citation:
Assignee:
IRM,LLC
International Classes:
C07D471/04; A61K31/4375; A61K31/519; A61K31/5377; A61P1/16; A61P7/02; A61P9/00; A61P9/12; A61P11/00; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P25/28; A61P27/02; A61P35/00; A61P35/02; A61P37/00; A61P37/06; A61P43/00; C07D487/04
Domestic Patent References:
| JP2006511563A | 2006-04-06 |
Foreign References:
| WO2005011597A2 | 2005-02-10 | |||
| WO2005034869A2 | 2005-04-21 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Aoyama Aoi
Mitsutaka Iwasaki
Aoyama Aoi
Mitsutaka Iwasaki