Title:
免疫治療のための組成物および方法
Document Type and Number:
Japanese Patent JP7076493
Kind Code:
B2
Abstract:
The present invention provides immunoresponsive cells, including T cells, cytotoxic T cells, regulatory T cells, and Natural Killer (NK) cells, expressing an antigen recognizing receptor and an inhibitory chimeric antigen receptor (iCAR). Methods of using the immunoresponsive cell include those for the treatment of neoplasia and other pathologies where an increase in an antigen-specific immune response is desired.
Inventors:
Victor Dee Fedrov
Michelle Saderain
Michelle Saderain
Application Number:
JP2020077143A
Publication Date:
May 27, 2022
Filing Date:
April 24, 2020
Export Citation:
Assignee:
Memorial Sloan Kettering Cancer Center
International Classes:
C12N5/10; A61K35/17; A61K35/545; A61P35/00; C07K14/705; C12N15/62
Foreign References:
| WO2008038587A1 |
Other References:
ROSENBERG J. et al.,Curr Opin Chem Eng.,2018年,19,p.9-20
Chicaybam L. et al.,A conditional system for the activation of lymphocytes expressing activating and inhibitory CARs.,Human Gene Therapy,vol.21 no.10(2010),p.1418 P60
Chicaybam L. et al.,International Reviews of Immunology,30(2011),p.294-311
Chicaybam L. et al.,A conditional system for the activation of lymphocytes expressing activating and inhibitory CARs.,Human Gene Therapy,vol.21 no.10(2010),p.1418 P60
Chicaybam L. et al.,International Reviews of Immunology,30(2011),p.294-311
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki