Title:
組換えＧｐＩｂα受容体タンパク質を含む組成物
Document Type and Number:
Japanese Patent JP7373993
Kind Code:
B2
Abstract:
Various aspects of the invention relate to recombinant polypeptides that specifically bind human von Willebrand Factor. Such recombinant polypeptides typically include a modified extracellular domain of platelet glycoprotein Ibα that typically comprises at least one mutation selected from G233T, D235V, and K237V, and such recombinant polypeptides optionally include an oligomerization domain.
Inventors:
Elizabeth Booth
Virginia Montanini
John A. Hall
Jody Berry
Virginia Montanini
John A. Hall
Jody Berry
Application Number:
JP2019533522A
Publication Date:
November 06, 2023
Filing Date:
February 15, 2019
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07K14/745; C07K14/435; C07K14/705; C07K16/00; C07K17/00; C07K19/00; C12M1/34; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/62; G01N33/53; G01N33/531; G01N33/544
Domestic Patent References:
| JP200573528A | ||||
| JP2010532467A | ||||
| JP2007537710A |
Other References:
MARCHESE,p. et al.,Proc. Natl. Acad. Sci. USA, 1999年, Vol.96, p7837ー7842
MATSUBARA, Y. et al., J. Thromb. Heamost., 2003年, Vol.1, p2198-2205
FLOOD, V.H. et al., Blood, 2011年, Vol.117, No.6, pe67ーe74
MATSUBARA, Y. et al., J. Thromb. Heamost., 2003年, Vol.1, p2198-2205
FLOOD, V.H. et al., Blood, 2011年, Vol.117, No.6, pe67ーe74
Attorney, Agent or Firm:
Masato Iida
Shiojiri Kazuhiro
Shiojiri Kazuhiro