Title:
COMPOSITIONS AND METHODS FOR ENHANCING CANCER CHEMOTHERAPY
Document Type and Number:
Japanese Patent JP2023115357
Kind Code:
A
Abstract:
To provide safe and effective compositions and methods to enhance the effectiveness and/or reduce the side effects of cancer chemotherapy and increase the sensitivity of chemotherapy resistant cancer cells.SOLUTION: A nutritional supplement that includes fish oil and selenium has been found to provide a variety of activities beneficial in treating cancer and associated conditions. Such a supplement provides synergistic effects in reducing cancer cell proliferation when used in combination with chemotherapeutic drugs, and can reduce proliferation in drug-resistant cancer cells when used in combination with chemotherapeutic drugs to which the cells are resistant. Effects in reducing angiogenesis, reducing metastasis, reducing the number of circulating cancer cells, and modifying AXL signaling were also found. In addition, use of such a supplement was found to reduce wasting associated with cachexia and reduce circulating cytokines associated with inflammation. Overall effects were found to extend survival in clinical studies.SELECTED DRAWING: Figure 1
Inventors:
HOUN SIMON HSIA
Application Number:
JP2023108547A
Publication Date:
August 18, 2023
Filing Date:
June 30, 2023
Export Citation:
Assignee:
HOUN SIMON HSIA
International Classes:
A61K35/60; A61K31/337; A61K31/517; A61K31/519; A61K31/5377; A61K31/704; A61K33/04; A61K33/243; A61K39/395; A61K45/00; A61P35/00; A61P43/00
Attorney, Agent or Firm:
Patent Attorney Corporation R&C