Title:
COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION OF Hif2α
Document Type and Number:
Japanese Patent JP2022001576
Kind Code:
A
Abstract:
To provide RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hif2α (EPAS1) gene.SOLUTION: RNA interference (RNAi) triggers and RNAi trigger conjugates for inhibiting the expression of Hif2α (EPAS1) gene are provided. Pharmaceutical compositions comprising one or more Hif2α RNAi triggers optionally with one or more additional therapeutics are also provided. Delivery of the described Hif2α RNAi triggers to tumor cells in vivo provides inhibition of Hif2α gene expression and treatment of cancer.SELECTED DRAWING: Figure 1
Inventors:
WONG SO
DAVID L LEWIS
DAVID B ROZEMA
DARREN H WAKEFIELD
CHENG WEIJUN
LAUREN J ALMEIDA
ANDREI V BLOKHIN
JEFFREY C CARLSON
ANTHONY L NICHOLAS
AARON ALMEIDA
STEVEN B KANNER
JONATHAN D BENSON
JUSTIN WOODS
DAVID L LEWIS
DAVID B ROZEMA
DARREN H WAKEFIELD
CHENG WEIJUN
LAUREN J ALMEIDA
ANDREI V BLOKHIN
JEFFREY C CARLSON
ANTHONY L NICHOLAS
AARON ALMEIDA
STEVEN B KANNER
JONATHAN D BENSON
JUSTIN WOODS
Application Number:
JP2021151282A
Publication Date:
January 06, 2022
Filing Date:
September 16, 2021
Export Citation:
Assignee:
ARROWHEAD RES CORP
International Classes:
A61K48/00; A61K31/713; A61K45/00; A61K47/56; A61K47/60; A61K47/64; A61P35/00; A61P43/00; C12N5/09; C12N5/10; C12N15/113; C12N15/88
Domestic Patent References:
| JP2011516065A | 2011-05-26 |
Foreign References:
| WO2014134255A2 | 2014-09-04 | |||
| WO2012174224A2 | 2012-12-20 |
Attorney, Agent or Firm:
Atsushi Aoki
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kumi Kitamura
Shinji Mitsuhashi
Yoichi Watanabe
Masaru Nakajima
Ryotaro Takei
Kumi Kitamura