COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

Title:

COMPOSITIONS AND METHODS TO PREVENT TOXICITY INDUCED BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

Document Type and Number:

Japanese Patent JP2007291127

Kind Code:

A

Abstract:

To provide nonsteroidal antiinflammatory drugs preventing, reducing toxicities such as gastrointestinal lesions.

Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.

Inventors:

GARVEY DAVID S
LETTS L GORDON
RENFROE H BURT
TAM SANG W

Application Number:

JP2007167646A

Publication Date:

November 08, 2007

Filing Date:

June 26, 2007

Export Citation:

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Assignee:

NITROMED INC

International Classes:

A61K45/00; C07D417/04; A61K31/00; A61K31/19; A61K31/403; A61K31/404; A61K31/405; A61K31/54; A61K31/541; A61K31/5415; A61K31/575; A61K38/00; A61P1/00; A61P1/04; A61P29/00; A61P43/00; C07C203/00; C07C327/28; C07C381/00; C07D209/28; C07D417/12; C07J41/00; C07K5/02

Foreign References:

WO1994012463A1	1994-06-09
WO1995009831A1	1995-04-13
WO1995007691A1	1995-03-23

Attorney, Agent or Firm:

Hatsushi Shimizu
Koichi Niimi

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