Title:
COMPOSITIONS FOR SMALL MOLECULE THERAPEUTIC AGENT COMPOUNDS
Document Type and Number:
Japanese Patent JP2022188046
Kind Code:
A
Abstract:
To provide compositions and formulations for a small molecule therapeutic agent, and also to provide drug delivery devices comprising the compositions and formulations for controlled, sustained delivery of the small molecule therapeutic agent.SOLUTION: Provided is a composition that comprises an aqueous suspension comprising a small molecule therapeutic agent and an organic acid. The small molecule therapeutic agent is a base and has a water solubility at room temperature of less than about 1.0 g/L. The organic acid has a water solubility at room temperature of between 0.1 and 10, has a molar mass of less than 500 grams per mole, and/or maintains a pH of the suspension in its environment of use of between 3.0 and 6.5. The organic acid enhances the solubility of the small molecule therapeutic agent, and when present in stoichiometric excess, the organic acid drives release of the small molecule therapeutic agent into a buffered environment of use for prolonged periods of, for example, six months to one year. Devices comprising the compositions and methods of treatment are also described.SELECTED DRAWING: None
Inventors:
Gregory A. Watkins
Application Number:
JP2022144103A
Publication Date:
December 20, 2022
Filing Date:
September 09, 2022
Export Citation:
Assignee:
Delpor, Inc.
International Classes:
A61K47/12; A61K9/00; A61K9/10; A61K9/14; A61K9/20; A61K9/70; A61K31/407; A61K31/496; A61K31/519; A61K31/5513; A61K45/00; A61K47/22; A61K47/36; A61P25/18
Attorney, Agent or Firm:
Yamato Kento
Yasushi Ochiai
Kojiro Hayashi
Yasushi Ochiai
Kojiro Hayashi