COMPOSITIONS FOR TREATING INFLAMMATORY AUTOIMMUNE CONDITION

Japanese Patent JP2014167019

A

PROBLEM TO BE SOLVED: To provide a medicament comprising human Tr1 cells directed to a human heat shock protein (HSP), and methods for treating an inflammatory autoimmune condition.SOLUTION: The invention provides pharmaceutical compositions in which human Tr1 cell populations for treating an inflammatory autoimmune condition are preferably HSP60, HSP70, HSP90 and fragments or mixtures thereof. The invention also provides use of the compositions in combination with one or more effective therapeutic agents. The invention further provides methods of administering 10to 10/kg Tr1 cells to a subject in need thereof.

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ARNAUD FOUSSAT
VALERIE BRUN

JP2014100525A

September 11, 2014

May 14, 2014

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A61K35/12; A61K31/135; A61K31/136; A61K31/198; A61K31/42; A61K31/4706; A61K31/519; A61K31/52; A61K31/573; A61K31/575; A61K31/58; A61K31/606; A61K31/616; A61K31/635; A61K31/65; A61K31/675; A61K35/17; A61K38/00; A61K38/16; A61K38/17; A61K38/21; A61K39/00; A61K39/395; A61K45/00; A61P1/04; A61P1/16; A61P9/00; A61P9/10; A61P11/06; A61P19/02; A61P25/00; A61P29/00; A61P37/06; C12N5/0783

JP5619727B2	2014-11-05
JP2004208548A	2004-07-29

WO2007121233A1	2007-10-25
WO2007066313A2	2007-06-14
WO2008126940A1	2008-10-23

JPN6013042024; Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｉｎｖｅｓｔｉｇａｔｉｏｎ １１６（７）, 2006, ｐ．２０２２-２０３２
JPN6013042026; Ｒｈｅｕｍａｔｏｌｏｇｙ ４１, 2002, ｐ．７７５-７７９
JPN6013042023; Ｉｎｔ．　Ｉｍｍｕｎｏｌ． １０（２）, 1998, ｐ．１１７-１３０

Ryoichi Takaoka

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