Title:
嚢胞性線維症および他の慢性疾患の治療のための組成物
Document Type and Number:
Japanese Patent JP2013508414
Kind Code:
A
Abstract:
The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one compound of Formula I, Formula II, or Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.
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Inventors:
Bang Gore, Frederick F.
Burton, William Lawrence
Burton, William Lawrence
Application Number:
JP2012535433A
Publication Date:
March 07, 2013
Filing Date:
October 22, 2010
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K45/00; A61K31/404; A61K31/443; A61K31/47; A61K31/4965; A61K31/497; A61K31/506; A61K31/5377; A61K31/541; A61P1/10; A61P1/16; A61P1/18; A61P3/00; A61P3/10; A61P5/10; A61P5/14; A61P5/16; A61P7/00; A61P11/00; A61P11/06; A61P13/02; A61P13/12; A61P15/08; A61P17/00; A61P17/06; A61P19/08; A61P19/10; A61P21/00; A61P21/04; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P27/16; A61P31/10; A61P35/00; A61P37/06; A61P43/00; C07D403/12; C07D471/10; C07D487/04; C07D487/10; C07D519/00
Domestic Patent References:
| JP2009536969A | 2009-10-22 |
Foreign References:
| WO2009074575A2 | 2009-06-18 | |||
| US4501729A | 1985-02-26 | |||
| US5876700A | 1999-03-02 | |||
| WO2006002421A2 | 2006-01-05 | |||
| WO2009073757A1 | 2009-06-11 | |||
| US20090131492A1 | 2009-05-21 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita