COMPOUND AND ASYMMETRIC SYNTHESIS REACTION - INST OF MICROBIAL CHEMISTRY

Title:

COMPOUND AND ASYMMETRIC SYNTHESIS REACTION

Document Type and Number:

Japanese Patent JP2013121935

Kind Code:

A

Abstract:

To provide a novel compound capable of inexpensively synthesizing a compound useful for producing pharmaceuticals such as an anti-hepatitis C virus drug by a synthetic organic chemistry method; and to provide an asymmetric synthesis reaction useful for synthesizing compounds containing the novel compound.

Provided is a compound represented by general formula (1) (wherein R¹ is either a protecting group for a hydroxyl group or a hydrogen atom; and R² is either a methyl group or an ethyl group).

Inventors:

SHIBAZAKI MASAKATSU
KUMAGAI NAOYA

Application Number:

JP2011271563A

Publication Date:

June 20, 2013

Filing Date:

December 12, 2011

Export Citation:

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Assignee:

INST OF MICROBIAL CHEMISTRY

International Classes:

C07D307/33; B01J31/24; C07C323/12; C07D301/02; C07D303/22; C07D309/30; C07B53/00; C07B61/00

Domestic Patent References:

JP2002275127A	2002-09-25
JP2002275127A	2002-09-25

Foreign References:

WO2004071503A1	2004-08-26
US5693847A	1997-12-02
WO2004071503A1	2004-08-26
US5693847A	1997-12-02

Other References:

JPN7013000511; 江角朋之他: 'ビリジオファンジンＡの合成と絶対構造の決定' 第３９回天然有機化合物討論会講演要旨集 , 19970720, ｐ．４０９-４１４
JPN6013006394; Ｂａｒｒｙ　Ｍ．　Ｔｒｏｓｔ　ｅｔ　ａｌ: 'Ａ　ｓｙｎｔｈｅｔｉｃ　ａｐｐｒｏａｃｈ　ｔｏ　ｐｏｌｙｅｎｅ　ｍａｃｒｏｌｌｄｅｓ：　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｔｈｅ　ｂｕｉｌｄｉｎｇ　ｂｌｏｃｋｓ' Ｔｅｔｒａｈｅｄｒｏｎ　ＬｅｔｔｅｒｓＶｏｌ．２７，　Ｎｏ．４７, 1986, ｐ．５６９１-５６９４
JPN6013006396; Ｋａｚｕｈｉｋｏ　Ｔａｎａｋａ　ｅｔ　ａｌ: 'Ｎｅｗ　Ｍｅｔｈｏｄｓ　ｆｏｒ　Ｓｔｅｒｅｏｓｅｌｅｃｔｉｖｅ　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　alpha-Ａｌｋｙｌｉｄｅｎｅ-gamma-ｂｕｔｙｒｏｌａｃｔｏｎｅｓ　Ｕｓｉｎｇ　Ｍｏｎｏａｎｉｏｎ　ｏｆ　Ｏ-Ｅｔ' Ｂｕｌｌｅｔｉｎ　ｏｆ　ｔｈｅ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ　ｏｆ　ＪａｐａｎＶｏｌ．５３，　Ｎｏ．１０, 1980, ｐ．２９１０-２９１６
JPN6013006391; 武智翔他: 'alpha-チオラクトンを求核剤とするジアステレオ選択的触媒的不斉ダイレクトアルドール反応' 日本薬学会第１３２年会要旨集２ , 20120305, ｐ．１５４
JPN6013006390; Ｓｈｏ　Ｔａｋｅｃｈｉ　ｅｔ　ａｌ: 'Ａ　Ｄｉｒｅｃｔ　Ｃａｔａｌｙｔｉｃ　Ａｓｙｍｍｅｔｒｉｃ　Ａｌｄｏｌ　Ｒｅａｃｔｉｏｎ　ｏｆ　ａ-Ｓｕｌｆａｎｙｌ　Ｌａｃｔｏｎｅｓ：Ｅｆｆｉｃｉｅｎｔ　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　ＳＰＴ　Ｉｎｈｉｂ' Ａｎｇｅｗａｎｄｔｅ　Ｃｈｅｍｉｅ　Ｉｎｔｅｒｎａｔｉｏｎａｌ　ＥｄｉｔｉｏｎＶｏｌ．５１，　Ｎｏ．１７, 20120423, ｐ．４２１８-４２２２
JPN7013000511; 江角朋之他: 'ビリジオファンジンＡの合成と絶対構造の決定' 第３９回天然有機化合物討論会講演要旨集 , 19970720, ｐ．４０９-４１４
JPN6013006394; Ｂａｒｒｙ　Ｍ．　Ｔｒｏｓｔ　ｅｔ　ａｌ: 'Ａ　ｓｙｎｔｈｅｔｉｃ　ａｐｐｒｏａｃｈ　ｔｏ　ｐｏｌｙｅｎｅ　ｍａｃｒｏｌｌｄｅｓ：　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　ｔｈｅ　ｂｕｉｌｄｉｎｇ　ｂｌｏｃｋｓ' Ｔｅｔｒａｈｅｄｒｏｎ　ＬｅｔｔｅｒｓＶｏｌ．２７，　Ｎｏ．４７, 1986, ｐ．５６９１-５６９４
JPN6013006396; Ｋａｚｕｈｉｋｏ　Ｔａｎａｋａ　ｅｔ　ａｌ: 'Ｎｅｗ　Ｍｅｔｈｏｄｓ　ｆｏｒ　Ｓｔｅｒｅｏｓｅｌｅｃｔｉｖｅ　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　alpha-Ａｌｋｙｌｉｄｅｎｅ-gamma-ｂｕｔｙｒｏｌａｃｔｏｎｅｓ　Ｕｓｉｎｇ　Ｍｏｎｏａｎｉｏｎ　ｏｆ　Ｏ-Ｅｔ' Ｂｕｌｌｅｔｉｎ　ｏｆ　ｔｈｅ　Ｃｈｅｍｉｃａｌ　Ｓｏｃｉｅｔｙ　ｏｆ　ＪａｐａｎＶｏｌ．５３，　Ｎｏ．１０, 1980, ｐ．２９１０-２９１６
JPN6013006391; 武智翔他: 'alpha-チオラクトンを求核剤とするジアステレオ選択的触媒的不斉ダイレクトアルドール反応' 日本薬学会第１３２年会要旨集２ , 20120305, ｐ．１５４
JPN6013006390; Ｓｈｏ　Ｔａｋｅｃｈｉ　ｅｔ　ａｌ: 'Ａ　Ｄｉｒｅｃｔ　Ｃａｔａｌｙｔｉｃ　Ａｓｙｍｍｅｔｒｉｃ　Ａｌｄｏｌ　Ｒｅａｃｔｉｏｎ　ｏｆ　ａ-Ｓｕｌｆａｎｙｌ　Ｌａｃｔｏｎｅｓ：Ｅｆｆｉｃｉｅｎｔ　Ｓｙｎｔｈｅｓｉｓ　ｏｆ　ＳＰＴ　Ｉｎｈｉｂ' Ａｎｇｅｗａｎｄｔｅ　Ｃｈｅｍｉｅ　Ｉｎｔｅｒｎａｔｉｏｎａｌ　ＥｄｉｔｉｏｎＶｏｌ．５１，　Ｎｏ．１７, 20120423, ｐ．４２１８-４２２２

Attorney, Agent or Firm:

Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda

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