Title:
COMPOUND FOR CURING INFLAMMATORY DISORDER
Document Type and Number:
Japanese Patent JP2010006817
Kind Code:
A
Abstract:
To provide a hydroxamic acid or carboxylic acid-functional compound (which can inhibit production of a tumor necrosis factor alpha (TNF-)), a pharmaceutical composition containing such a compound and a curing method using such a compound.
The compound provides a new kind of MMP and TNF- conversion enzyme inhibitor, a pharmaceutical composition containing one or more kinds of the compound, a method for preparing a pharmaceutical formulation containing one or more kinds of such compounds and a method for curing, preventing or improving one or more symptoms of inflammation. The compound can be given in a nasal formula through local use of a proper nasal vehicle or a dermal pathway by using a dermal absorption patch known to those of skill in the art. For the administration in the form of a dermal delivery system, the dosage administration is, of course, continuous rather than intermittently over the whole administration regimen.
Inventors:
ZHU ZHAONING
MAZZOLA ROBERT JR
GUO ZHUYAN
LAVEY BRIAN J
SINNING LISA
KOZLOWSKI JOSEPH
MCKITTRICK BRIAN
SHIH NENG-YANG
Application Number:
JP2009188147A
Publication Date:
January 14, 2010
Filing Date:
August 14, 2009
International Classes:
C07C259/08; A61K31/165; C07D249/06; A61K31/167; A61K31/194; A61K31/215; A61K31/216; A61K31/225; A61K31/275; A61K31/277; A61K31/353; A61K31/36; A61K31/4164; A61K31/4192; A61K31/428; A61K31/435; A61K31/44; A61K31/4406; A61K31/4409; A61K31/47; A61K31/4709; A61K31/495; A61K31/496; A61K31/5377; A61P1/00; A61P1/02; A61P1/04; A61P1/16; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P11/00; A61P11/02; A61P11/06; A61P13/02; A61P13/12; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P19/10; A61P21/00; A61P25/00; A61P27/02; A61P27/06; A61P29/00; A61P31/04; A61P31/18; A61P33/06; A61P35/00; A61P35/04; A61P37/02; A61P37/06; A61P37/08; C07C61/39; C07C62/34; C07C69/757; C07C233/63; C07C235/40; C07C255/54; C07C279/08; C07C311/21; C07C311/29; C07C317/22; C07C323/19; C07D213/30; C07D213/40; C07D213/53; C07D213/73; C07D213/74; C07D215/14; C07D215/18; C07D215/233; C07D215/26; C07D215/38; C07D219/02; C07D221/16; C07D233/54; C07D233/58; C07D233/64; C07D249/04; C07D271/06; C07D277/24; C07D277/44; C07D277/64; C07D295/14; C07D295/18; C07D311/58; C07D311/74; C07D317/64; C07D401/04; C07D401/12; C07D413/12; C07D417/12; C07D215/22
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
