Title:
COMPOUND INHIBITING RETROVIRUS PROTEASE
Document Type and Number:
Japanese Patent JP3812969
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain the subject new compound having a specific molecular structure, exhibiting an action on the inhibition of a retrovirus protease, and useful for the therapy of retrovirus infection, especially human immunodeficiency virus(HIV) infection causing AIDS, etc.
SOLUTION: A new compound of formula I [R1 is a mono-substituted (iso) thiazolyl, a mono-substituted (iso)oxazolyl; (n) is 1-3; R2, R6 are each H, a lower alkyl; R3 is a lower alkyl; R4, R4a are each a (substituted)phenyl, a (substituted) thiazolyl; R7 is a (substituted) (iso)thiazolyl, a (substituted) (iso)oxazolyl; X is H and Y is OH, or X is OH and Y is H, etc.; Z is absent, O, S, CH2, etc.,]. The compound of formula I is useful for the therapy of retrovirus infection, etc. The compound is obtained by reacting an amino group-containing compound of formula II with an N-substitute amino acid of formula III or its active ester derivative.
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Inventors:
Dale Jay Kemp
Daniel D'Abrieu Novetsk
Hin Rune Siam
Chiang Suao
Thomas the ray sowyn
Daniel S. Reno
Anthony Earl Height
Arthur Jay Cooper
Daniel D'Abrieu Novetsk
Hin Rune Siam
Chiang Suao
Thomas the ray sowyn
Daniel S. Reno
Anthony Earl Height
Arthur Jay Cooper
Application Number:
JP13236896A
Publication Date:
August 23, 2006
Filing Date:
May 27, 1996
Export Citation:
Assignee:
Abbot Laboratories
International Classes:
C07D275/02; C07D417/12; A61K31/395; A61K31/415; A61K31/4164; A61K31/42; A61K31/421; A61K31/422; A61K31/425; A61K31/426; A61K31/427; A61K31/535; A61K31/5375; A61K31/5377; A61K31/54; A61K45/06; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/04; A61P43/00; C07C33/46; C07C43/164; C07C43/174; C07C43/205; C07C43/215; C07C43/23; C07C43/30; C07C43/315; C07C45/00; C07C45/29; C07C45/56; C07C45/62; C07C45/67; C07C45/74; C07C53/134; C07C69/34; C07C69/65; C07C69/732; C07C211/27; C07C215/18; C07C215/20; C07C215/28; C07C229/08; C07C229/26; C07C229/34; C07C233/36; C07C233/40; C07C235/10; C07C235/12; C07C235/34; C07C235/78; C07C237/10; C07C237/20; C07C237/22; C07C239/10; C07C239/18; C07C239/20; C07C247/10; C07C251/40; C07C271/20; C07C271/22; C07C271/34; C07C275/16; C07C275/24; C07C311/03; C07C311/13; C07C311/18; C07C317/10; C07C317/28; C07C317/44; C07C323/12; C07C323/25; C07C381/00; C07D213/26; C07D213/30; C07D213/34; C07D213/40; C07D213/54; C07D213/56; C07D213/61; C07D213/75; C07D233/54; C07D233/84; C07D235/14; C07D235/16; C07D239/26; C07D241/12; C07D261/06; C07D261/08; C07D263/24; C07D263/30; C07D263/32; C07D263/48; C07D265/30; C07D277/22; C07D277/24; C07D277/28; C07D277/30; C07D277/32; C07D277/34; C07D277/36; C07D277/40; C07D277/42; C07D277/56; C07D295/13; C07D295/205; C07D295/215; C07D303/36; C07D307/42; C07D333/16; C07D401/12; C07D413/12; C07D413/14; C07D417/14; C07D521/00; C07F5/02; C07F5/04; C07K5/06; C07K5/065; A61K38/00; C07D235/10; C07D; (IPC1-7): C07D417/12; C07D417/12; C07D417/12; A61K31/42; A61K31/425; A61K31/425; A61K31/535; A61K31/54; C07D261/08; C07D263/32; C07D265/30; C07D275/02; C07D277/24; C07D277/28; C07D413/12; C07D417/14
Domestic Patent References:
JP4308574A | ||||
JP242048A |
Attorney, Agent or Firm:
Yoshio Kawaguchi