COMPOUND AND METHOD FOR DECOMPOSING AND IMPROVING TARGET PROTEIN

Japanese Patent JP2023109967

A

To provide a bifunctional compound useful as ubiquitinated modulator subjected to targeting and useful as an inhibitor of various polypeptides decomposed by the bifunctional compound and/or obstructed in the other manners and the other proteins.SOLUTION: The bifunctional compound having the following formula includes a Von Hippel Lindau (VHL) E3 ubiquitin ligase bonding part (ULM) directly or connected through a chemicals linker (L) and a protein targeting part (PTM). The ULM is the group of the following chemical structure or salt pharmacologically allowed, a stereoisomer, a solvate or a polymorph.SELECTED DRAWING: Figure 1

MICHAEL BERLIN
KURT ZIMMERMANN
LAWRENCE SNYDER
ANDREW P CREW
CRAIG M CREWS
CHEN QING
DONG HANQING
FERRARO CATERINA
JIN MEIZHONG
QIAN YIMIN
SIU KAM
WANG JIN

JP2023087483A

August 08, 2023

May 29, 2023

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ARVINAS OPERATIONS INC
UNIV YALE

C07D417/14; A61K31/422; A61K31/427; A61K31/433; A61K31/4439; A61K31/444; A61K31/497; A61K31/501; A61K31/549; A61K31/551; A61K38/05; A61K45/00; A61P1/02; A61P1/04; A61P1/14; A61P1/16; A61P1/18; A61P3/00; A61P3/02; A61P3/04; A61P3/10; A61P5/06; A61P5/26; A61P7/00; A61P7/02; A61P7/04; A61P7/06; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/04; A61P11/06; A61P13/02; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P15/08; A61P17/00; A61P17/06; A61P19/02; A61P19/08; A61P21/00; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P27/10; A61P27/16; A61P29/00; A61P35/00; A61P35/02; A61P37/04; A61P43/00; C07D413/14; C07D417/12; C07D495/14; C07K5/078

Hatsushi Shimizu
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto

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