Title:
CRTH2アンタゴニスト活性を有する化合物
Document Type and Number:
Japanese Patent JP2011509988
Kind Code:
A
Abstract:
Compounds of general formula (I) wherein W is chloro or fluoro; R1 is phenyl optionally substituted with one or more substituents selected from halo, -CN, -C1-C6 alkyl, -SOR3, -SO2R3, -SO2N(R2)2, -N(R2)2, -NR2C(O)R3, -CO2R2, -CONR2R3, -NO2, -OR2, -SR2, -O(CH2)pOR2, and -O(CH2)p-O-(CH2)qOR2 wherein each R2 is independently hydrogen, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; each R3 is independently, -C1-C6 alkyl, -C3-C8 cycloalkyl, aryl or heteroaryl; p and q are each independently an integer from 1 to 3; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis.
Inventors:
Almar richard edward
Petty fur eric roy
Wittaker mark
Wine Graham Michael
Weill Julia
Schroar Frank
Petty fur eric roy
Wittaker mark
Wine Graham Michael
Weill Julia
Schroar Frank
Application Number:
JP2010542688A
Publication Date:
March 31, 2011
Filing Date:
January 19, 2009
Export Citation:
Assignee:
Oxagen Limited
International Classes:
C07D401/06; A61K31/4439; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P9/00; A61P9/10; A61P11/02; A61P11/06; A61P11/14; A61P13/02; A61P13/08; A61P13/10; A61P13/12; A61P15/10; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/10; A61P17/14; A61P19/02; A61P19/06; A61P21/04; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/12; A61P31/16; A61P35/00; A61P37/06; A61P37/08
Domestic Patent References:
| JP2011506415A | 2011-03-03 | |||
| JP2011503045A | 2011-01-27 | |||
| JPS57181082A | 1982-11-08 | |||
| JP2010500966A | 2010-01-14 |
Foreign References:
| WO2006095183A1 | 2006-09-14 |
Attorney, Agent or Firm:
Masayuki Masabayashi
Hayashi Ichiyoshi
Hayashi Ichiyoshi