化合物 - SmithKline Beechham Corporation

Title:

化合物

Document Type and Number:

Japanese Patent JP2007519754

Kind Code:

A

Abstract:

There is provided compounds of Formula (I) and salts, solvates, and physiologically functional derivatives thereof: wherein R1 is hydrogen or C_1-6alkyl; n is 1, 2, 3 or 4; R2 is aryl, optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, C_1-4alkyl, C_1-4alkoxy, C_1-4alkanoyl, haloC_1-4alkyl, haloC_1-4alkoxy, aryl, aryloxy, C_1-4alkoxycarbonyl, C_1-4alkylsulfonyl and a group R3R4NSO₂(wherein R3 and R4 are independently hydrogen or C_1-4alkyl) and a 5- or 6-membered heteroaryl group; or n is 0 and R1 and R2, together with the nitrogen atom to which they are joined, form a 5- or 6-membered monocyclic heterocyclic ring or a 9- or 10-membered bicyclic heterocyclic ring wherein at least the ring which contains the nitrogen atom to which R1 and R2 are joined is non-aromatic, and wherein the 5- or 6-membered monocyclic heterocyclic ring or the 9- or 10-membered bicyclic heterocyclic ring is optionally substituted by one or two groups selected from the group consisting of halogen, hydroxy, cyano, oxo, C_1-4alkyl, C_1-4alkanoyl, C_1-4alkoxy, haloC_1-4alkyl, haloC_1-4alkoxy, aryl, aryloxy and C_1-4alkoxycarbonyl; and X is indazolyl, pyrazolyl or a group: wherein G is CH or N; and Y₁and Y₂are independently hydrogen, halogen and a group NR5R6 (wherein R5 and R6 are independently hydrogen, C_1-6alkyl or C_2-6alkenyl).

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Inventors:

Drury, David, Harold
Jung, David, Kendall
Lynn, James, Andrew
Hunter, Robert, Neil, The Third
Lee, Dennis
Stevenger, Robert, A
Sehon, Clark

Application Number:

JP2006551626A

Publication Date:

July 19, 2007

Filing Date:

January 28, 2005

Export Citation:

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Assignee:

SmithKline Beechham Corporation

International Classes:

C07D213/56; A61K31/416; A61K31/4164; A61K31/4409; A61K31/505; A61K31/506; A61P1/04; A61P9/00; A61P9/04; A61P9/08; A61P9/10; A61P9/12; A61P11/06; A61P13/10; A61P13/12; A61P15/10; A61P21/04; A61P25/00; A61P25/02; A61P25/10; A61P25/16; A61P25/28; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P35/04; A61P43/00; C07D213/61; C07D231/56; C07D233/64; C07D239/26; C07D239/42; C07D401/04; C07D403/04

Foreign References:

WO2003087057A1	2003-10-23
WO2002064545A1	2002-08-22
WO2003024448A2	2003-03-27

Attorney, Agent or Firm:

Yusuke Hiraki
Ishii Teiji
Satoshi Fujita

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