Title:
銅含有アミンオキシダーゼを阻害するための化合物およびその使用
Document Type and Number:
Japanese Patent JP2008508348
Kind Code:
A
Abstract:
This invention is directed to inhibitors of copper-containing amine oxidases (E.C.1.4.3.6) including semicarbazide-sensitive amine oxidase (SSAO; also known as vascular adhesion protein-1, VAP-I), and their therapeutic use in inflammatory diseases, diabetes and its associated complications, atherosclerosis, neurodegenerative diseases, obesity, hypertension and cancer.
Inventors:
Luc Marti Closelle
Sylvia Garcia Vicente
Francesque iraora font
Miriam Royo Esposito
Sylvia Garcia Vicente
Francesque iraora font
Miriam Royo Esposito
Application Number:
JP2007524343A
Publication Date:
March 21, 2008
Filing Date:
August 02, 2005
Export Citation:
Assignee:
GENMEDICA THERAPEUTICS SL
International Classes:
C07C259/06; A61K31/165; A61K31/166; A61K31/167; A61K31/18; A61K31/198; A61K31/401; A61K31/404; A61K31/405; A61K31/47; A61K31/4709; A61K31/4725; A61P1/00; A61P1/02; A61P1/04; A61P1/18; A61P3/00; A61P3/04; A61P3/10; A61P7/00; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P25/00; A61P25/04; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/04; A61P35/00; A61P37/02; A61P37/08; A61P43/00; C07C233/51; C07C237/30; C07C237/32; C07C259/10; C07C311/19; C07C311/38; C07D207/16; C07D209/18; C07D209/42; C07D215/36; C07D401/06
Domestic Patent References:
| JP2001526245A | 2001-12-18 | |||
| JP2001507342A | 2001-06-05 | |||
| JP2001513484A | 2001-09-04 | |||
| JP2001526245A | 2001-12-18 | |||
| JP2001507342A | 2001-06-05 | |||
| JP2001513484A | 2001-09-04 |
Foreign References:
| EP1331224A1 | 2003-07-30 | |||
| US20040122011A1 | 2004-06-24 | |||
| EP1331224A1 | 2003-07-30 | |||
| US20040122011A1 | 2004-06-24 |
Other References:
JPN6010072387, ＫＯＢＡＳＨＩ，Ｋ． ｅｔ ａｌ, "Ｔｈｅｒａｐｙ ｆｏｒ ｕｒｏｌｉｔｈｉａｓｉｓ ｂｙ ｈｙｄｒｏｘａｍｉｃ ａｃｉｄｓ． ＩＩ． Ｕｒｅａｓｅ ｉｎｈｉｂｉｔｏｒｙ ｐｏｔｅｎｃｙ ａｎｄ ｕｒｉｎａｒｙ ｅｘｃｒｅｔｉｏｎ", Ｊｏｕｒｎａｌ ｏｆ Ｐｈａｒｍａｃｏｂｉｏ−Ｄｙｎａｍｉｃｓ, 1980, Ｖｏｌ．３， Ｎｏ．９, ｐ．４４４−５０
JPN6010072388, ＭＵＮＡＫＡＴＡ，Ｋ． ｅｔ ａｌ, "Ｔｈｅｒａｐｙ ｆｏｒ ｕｒｏｌｉｔｈｉａｓｉｓ ｗｉｔｈ ｈｙｄｒｏｘａｍｉｃ ａｃｉｄｓ． Ｉ． Ｓｙｎｔｈｅｓｉｓ ｏｆ ｎｅｗ Ｎ−（ａｒｏｙｌ）ｇｌｙｃｉｎｏｈｙｄｒｏｘａｍｉｃ ａｃｉ", Ｃｈｅｍｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ, 1980, Ｖｏｌ．２８， Ｎｏ．７, ｐ．２０４５−５１
JPN6010072388, ＭＵＮＡＫＡＴＡ，Ｋ． ｅｔ ａｌ, "Ｔｈｅｒａｐｙ ｆｏｒ ｕｒｏｌｉｔｈｉａｓｉｓ ｗｉｔｈ ｈｙｄｒｏｘａｍｉｃ ａｃｉｄｓ． Ｉ． Ｓｙｎｔｈｅｓｉｓ ｏｆ ｎｅｗ Ｎ−（ａｒｏｙｌ）ｇｌｙｃｉｎｏｈｙｄｒｏｘａｍｉｃ ａｃｉ", Ｃｈｅｍｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ, 1980, Ｖｏｌ．２８， Ｎｏ．７, ｐ．２０４５−５１
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Toshio Ueda
Nagatoshi Shinagawa
Samejima Mutsumi
Toshio Ueda
Nagatoshi Shinagawa