COMPOUNDS ACTIVE AT NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS AND NEUROPATHY

Title:

COMPOUNDS ACTIVE AT NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS AND NEUROPATHY

Document Type and Number:

Japanese Patent JP2014166987

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide compounds useful for curative treatment of neurodegenerative disease, or useful as a muscle relaxant, an analgesic, or an adjunct in general anesthesia.SOLUTION: The invention provides compounds represented by the specified structure or pharmaceutically acceptable salts thereof. [Each X is OH or OCH3; each R1 is independently C1-C5 lower alkyl; and each R2 is independently H or C1-C5 lower alkyl; where R1 and R2 on the nitrogen atom are identical.]

Inventors:

MUELLER ALAN L
VAN WAGENEN BRADFORD C
DELMAR ERIC G
BALANDRIN MANUEL F
MOE SCOTT T
ARTMAN LINDA D
BARMORE ROBERT M

Application Number:

JP2014005535A

Publication Date:

September 11, 2014

Filing Date:

January 16, 2014

Export Citation:

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Assignee:

NPS PHARMA INC

International Classes:

A61K31/405; C07C215/54; A61K31/135; A61K31/136; A61K31/137; A61K31/138; A61K31/14; A61K31/165; A61K31/17; A61K31/295; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61K31/4045; A61K31/4409; A61K31/4462; A61K31/4465; A61K45/00; A61P9/10; A61P9/12; A61P21/02; A61P23/00; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/22; A61P25/28; A61P43/00; C07C211/27; C07C211/29; C07C217/62; C07C233/22; C07C235/34; C07C237/22; C07C279/12; C07D209/18; G01N33/53; G01N33/566

Domestic Patent References:

JPH0899939A	1996-04-16
JP2012102130A	2012-05-31

Foreign References:

GB612301B

Attorney, Agent or Firm:

Seiji Ono
Reiko Tanaka
Keiko Kanamoto
Matto valley Yuko
Kitano 健
Ito 奈月

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