Title:
活性剤デリバリー用化合物および組成物
Document Type and Number:
Japanese Patent JP3647041
Kind Code:
B2
Abstract:
Modified amino acid compounds useful for the delivery of active agents are provided. The amino acids, non-alpha-amino acids, have been modified by acylation on the amino group particularly with phenyl or cyclohexyl groups. These groups have a variety of substituents including but not limited to hydroxy, methyl, fluoro, chloro, and the like. The compounds of the invention can be combined with numerous active agents including but not limited to heparin, peptides, and parathyroid hormone, and can then be used for effective administration of the active agent. Administration can be, for example, oral or parenteral.
Inventors:
Leone Bay, Andre
Ho, Kokkan
Salvi, donald jay
Milstein, Sam Jay
Press, Jeffrey Bruce
Ho, Kokkan
Salvi, donald jay
Milstein, Sam Jay
Press, Jeffrey Bruce
Application Number:
JP52975196A
Publication Date:
May 11, 2005
Filing Date:
April 01, 1996
Export Citation:
Assignee:
Emisfair Technologies Inc.
International Classes:
C07D295/20; A61K9/08; A61K9/16; A61K9/20; A61K9/48; A61K31/197; A61K31/198; A61K31/40; A61K31/44; A61K38/00; A61K38/04; A61K38/095; A61K38/21; A61K38/22; A61K38/23; A61K38/27; A61K38/28; A61K38/29; A61K39/00; A61K39/395; A61K45/00; A61K47/12; A61K47/16; A61K47/18; A61K47/20; A61K47/22; A61K47/48; C07C53/126; C07C53/134; C07C229/08; C07C229/10; C07C229/42; C07C231/12; C07C233/34; C07C233/47; C07C233/48; C07C233/51; C07C233/52; C07C233/54; C07C233/55; C07C233/63; C07C233/81; C07C233/83; C07C233/84; C07C233/87; C07C235/24; C07C235/34; C07C235/38; C07C235/40; C07C235/52; C07C235/56; C07C235/60; C07C235/62; C07C235/64; C07C235/78; C07C235/82; C07C235/84; C07C237/22; C07C237/40; C07C237/42; C07C239/06; C07C239/08; C07C259/06; C07C271/22; C07C303/22; C07C303/40; C07C309/59; C07C311/19; C07D207/34; C07D207/416; C07D213/75; C07D213/81; C07D295/215; C07D317/68; C07D333/38; A61K9/00; (IPC1-7): C07C235/84; A61K38/00; A61K38/04; A61K38/11; A61K38/21; A61K38/22; A61K38/28; A61K39/00; A61K39/395; A61K45/00
Domestic Patent References:
| JP63099048A | ||||
| JP63054322A | ||||
| JP62242623A | ||||
| JP51032538A | ||||
| JP51001440A | ||||
| JP51001439A | ||||
| JP51001438A | ||||
| JP49087692A |
Foreign References:
| WO1994021602A1 |
Other References:
MORRISON,R.T. et al., ORGANIC CHEMISTRY, THIRD EDITION , 1973年,p.671,672,755-758
Idoux,J.P. et al., Mode of Electronic Effect Transmission via the Amide Bond, J. Org. Chem., 1980年,Vol.45, p.441-444
Chemical Abstracts, 1969年,Vol.70, abstract no.114838e, p.310
Idoux,J.P. et al., Mode of Electronic Effect Transmission via the Amide Bond, J. Org. Chem., 1980年,Vol.45, p.441-444
Chemical Abstracts, 1969年,Vol.70, abstract no.114838e, p.310
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Takashi Watanabe