Title:
COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS
Document Type and Number:
Japanese Patent JP2023021468
Kind Code:
A
Abstract:
To provide novel lipids for intracellular delivery of therapeutic agents and compositions involving the same.SOLUTION: Nanoparticle compositions in the present disclosure include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic agents and/or prophylactics such as RNA are useful in the delivery of the therapeutic agents and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.SELECTED DRAWING: None
Inventors:
Benenato, Kelly E.
Kumarasinghe, Elarahewage Satyajit
Corne Vice, Mark
Kumarasinghe, Elarahewage Satyajit
Corne Vice, Mark
Application Number:
JP2022171116A
Publication Date:
February 13, 2023
Filing Date:
October 26, 2022
Export Citation:
Assignee:
ModernaTX,Inc.
International Classes:
A61K9/127; C07C229/12; A61K9/14; A61K9/51; A61K31/136; A61K31/519; A61K31/573; A61K45/00; A61K47/18; A61K47/20; A61K47/22; A61K47/24; A61K47/28; A61K47/44; A61P3/00; A61P3/10; A61P9/00; A61P13/12; A61P25/00; A61P31/00; A61P35/00; A61P37/02; C07C229/14; C07C229/16; C07C233/05; C07C233/36; C07C235/10; C07C237/06; C07C259/06; C07C271/12; C07C275/14; C07C279/12; C07C279/28; C07C279/36; C07C307/06; C07C311/05; C07C311/14; C07C311/48; C07C311/64; C07C317/44; C07C323/60; C07C335/08; C07D207/27; C07D209/48; C07D233/61; C07D233/74; C07D239/47; C07D239/545; C07D249/04; C07D263/22; C07D265/33; C07D271/06; C07D271/10; C07D277/42; C07D295/13; C07D295/135; C07D473/18; C07D473/34; C07F9/09
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Nakamura Miki
Hironobu Onda
Atsushi Honda
Nakamura Miki