COMPOUNDS, COMPOSITIONS AND METHODS

Japanese Patent JP2023060020

A

To provide methods of treating diseases.SOLUTION: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, stereoisomer mixture or prodrug thereof, and methods of making and using the same. The present disclosure relates generally to small molecule modulators of eukaryotic initiation factor 2B and use thereof as therapeutic agents, for example, in treating diseases mediated thereby such as Alzheimer's disease, Parkinson's disease, ALS, frontotemporal dementia and cancer.SELECTED DRAWING: None

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Robert A. Craig the Second
Anthony A. Estrada
Jianwen A. Feng
Katrina W. Lexa
Maxim Osipov
Zachary Kay. Sweeney
Javier de Vicente Fidalgo

JP2023030214A

April 27, 2023

February 28, 2023

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Denali Therapeutics Inc.

C07D309/14; A61K31/35; A61K31/351; A61K31/352; A61K31/4178; A61K31/4192; A61K31/422; A61K31/4245; A61K31/428; A61K31/437; A61K31/47; A61P3/10; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P31/00; A61P35/00; C07D311/02; C07D407/04; C07D407/14; C07D413/04; C07D413/14; C07D417/12; C07D471/04; C07D493/08

Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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