Title:
キナーゼ調節のための化合物、方法およびその適用
Document Type and Number:
Japanese Patent JP2013510166
Kind Code:
A
Abstract:
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, or forms thereof are active on Fms protein kinase, or on Fms and Kit protein kinase, or on Fms and Flt-3 protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Fms protein kinase, Kit protein kinase, or Flt-3 protein kinase including rheumatoid arthritis, osteoarthritis, multiple sclerosis, Alzheimer's disease, Parkinson's disease, glomerulonephritis, interstitial nephritis, Lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, acute myeloid leukemia, melanoma, multiple myeloma, metastatic breast cancer, prostate cancer, pancreatic cancer, neurofibromatosis, brain metastases, and gastrointestinal stromal tumors.
Inventors:
Jean Jajon
Prava N Ibrahim
Ryan Bremer
Wayne Spiback
Hannah Cho
Prava N Ibrahim
Ryan Bremer
Wayne Spiback
Hannah Cho
Application Number:
JP2012538002A
Publication Date:
March 21, 2013
Filing Date:
November 04, 2010
Export Citation:
Assignee:
PLEXXIKON INC.
International Classes:
C07D471/04; A61K31/444; A61K31/496; A61K31/506; A61K31/5377; A61P9/10; A61P13/12; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P35/00; A61P35/02; A61P35/04; A61P37/02; A61P43/00; C07D487/04
Domestic Patent References:
| JP2008545652A | 2008-12-18 | |||
| JP2008546797A | 2008-12-25 | |||
| JP2008503473A | 2008-02-07 | |||
| JP2010510321A | 2010-04-02 | |||
| JP2010514695A | 2010-05-06 |
Foreign References:
| WO2008064255A2 | 2008-05-29 | |||
| WO2008064265A2 | 2008-05-29 | |||
| WO2008080001A2 | 2008-07-03 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Hiroshi Sato
Kure Hidenori
Samejima Mutsumi
Masahiro Nitta
Hiroshi Sato
Kure Hidenori