Title:
標的タンパク質の分解向上のための化合物および方法
Document Type and Number:
Japanese Patent JP7269731
Kind Code:
B2
Abstract:
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins which are degraded and/or otherwise inhibited by bifunctional compounds according to the present invention. In particular, the present invention is directed to compounds, which contain on one end a VHL ligand which binds to the ubiquitin ligase and on the other end a moiety which binds a target protein such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of that protein. The present invention exhibits a broad range of pharmacological activities associated with compounds according to the present invention, consistent with the degradation/inhibition of targeted polypeptides.
Inventors:
berlin michael
Zimmerman Kart
snyder lawrence
Crew Andrew Pea.
Crews Craig M.
Chen Chin
Don Hankin
Ferraro Caterina
Jin Mae Chung
Chien Yimin
Shu Cam
Wang Jin
Zimmerman Kart
snyder lawrence
Crew Andrew Pea.
Crews Craig M.
Chen Chin
Don Hankin
Ferraro Caterina
Jin Mae Chung
Chien Yimin
Shu Cam
Wang Jin
Application Number:
JP2018500278A
Publication Date:
May 09, 2023
Filing Date:
March 18, 2016
Export Citation:
Assignee:
ARVINAS OPERATIONS, INC.
International Classes:
C07D417/14; A61K31/03; A61K31/166; A61K31/337; A61K31/427; A61K31/436; A61K31/4439; A61K31/444; A61K31/4545; A61K31/475; A61K31/506; A61K31/551; A61K31/5513; A61K31/704; A61K39/395; A61K47/60; A61P1/04; A61P3/06; A61P3/10; A61P5/14; A61P7/04; A61P7/06; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P15/00; A61P17/06; A61P19/02; A61P19/06; A61P21/00; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07D209/42; C07D211/60; C07D213/81; C07D233/16; C07D233/86; C07D239/48; C07D239/94; C07D261/18; C07D307/20; C07D401/04; C07D403/06; C07D403/12; C07D403/14; C07D405/04; C07D413/12; C07D413/14; C07D417/12; C07D471/04; C07D473/34; C07D487/04; C07D495/04; C07D495/14; C07J1/00
Foreign References:
| WO2013106643A2 | ||||
| WO2013106646A2 | ||||
| WO2015000867A1 | ||||
| WO2014108452A1 | ||||
| WO2016146985A1 | ||||
| WO2016118666A1 |
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
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