Title:
キナーゼ調節のための化合物及び方法ならびにそれらの適応症
Document Type and Number:
Japanese Patent JP5815558
Kind Code:
B2
Abstract:
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on each of B-Raf, B-Raf V600E and c-Raf-1 protein kinase. In certain aspects and embodiments, the described compounds are active in inhibiting proliferation of a Ras mutant cell line. Also described are methods of use thereof to treat diseases and conditions, including melanoma, glioma, glioblastoma, pilocytic astrocytoma, liver cancer, biliary tract cancer, cholangiocarcinoma, colorectal cancer, lung cancer, bladder cancer, gallbladder cancer, breast cancer, pancreatic cancer, thyroid cancer, kidney cancer, ovarian cancer, adrenocortical cancer, prostate cancer, gastrointestinal stromal tumors, medullary thyroid cancer, tumor angiogenesis, acute myeloid leukemia, chronic myelomonocytic leukemia, childhood acute lymphoblastic leukemia, plasma cell leukemia, and multiple myeloma.
Inventors:
Prava N Ibrahim
Guo Sien Wu
Jack Lynn
Wayne Spiback
Hannah Cho
Todd Ewing
Chao Jiang
Guo Sien Wu
Jack Lynn
Wayne Spiback
Hannah Cho
Todd Ewing
Chao Jiang
Application Number:
JP2012546158A
Publication Date:
November 17, 2015
Filing Date:
December 21, 2010
Export Citation:
Assignee:
PLEXXIKON INC.
International Classes:
C07D471/04; A61K31/437; A61K31/4709; A61K31/498; A61K31/517; A61K31/519; A61P35/00; A61P43/00; C07D519/00
Domestic Patent References:
| JP2008546797A | ||||
| JP2009077712A |
Foreign References:
| WO2008079903A1 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Kure Hidenori
Nobuhiko Akiyama
Samejima Mutsumi
Masahiro Nitta
Kure Hidenori
Nobuhiko Akiyama