Title:
タンパク質フォールディング障害を治療するための化合物および方法
Document Type and Number:
Japanese Patent JP2010510177
Kind Code:
A
Abstract:
The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, Aβ protein or α-synuclein protein aggregation.
Inventors:
Carter, Michael, Dee.
Weaver, Donald, F.
Jacobo, Sheila, Marie, H.
Lou, Aarhu
Gao, Huye
Weaver, Donald, F.
Jacobo, Sheila, Marie, H.
Lou, Aarhu
Gao, Huye
Application Number:
JP2009536575A
Publication Date:
April 02, 2010
Filing Date:
November 19, 2007
Export Citation:
Assignee:
Queens University at Kingston
International Classes:
C07C39/14; A61K31/05; A61K31/055; A61K31/136; A61K31/216; A61K31/343; A61K31/357; A61K31/381; A61K31/404; A61K31/437; A61K31/4402; A61K31/472; A61K31/4725; A61K31/473; A61K31/50; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C07C39/38; C07C65/05; C07C65/11; C07C69/76; C07C69/94; C07C215/82; C07C217/92; C07D209/08; C07D209/12; C07D209/14; C07D209/30; C07D209/42; C07D213/64; C07D217/00; C07D237/16; C07D307/80; C07D319/18; C07D333/56; C07D401/06; C07D403/04; C07D405/04; C07D409/04; C07D471/04
Domestic Patent References:
| JP2005526028A | 2005-09-02 | |||
| JP2005534619A | 2005-11-17 | |||
| JPH11228570A | 1999-08-24 | |||
| JP2004250411A | 2004-09-09 | |||
| JP2005516935A | 2005-06-09 | |||
| JPH07188010A | 1995-07-25 | |||
| JP2009511583A | 2009-03-19 | |||
| JP2010504326A | 2010-02-12 |
Foreign References:
| WO2005033059A1 | 2005-04-14 | |||
| WO2004100998A2 | 2004-11-25 |
Other References:
JPN6011007661; ＬＥＣＬＥＲＣ Ｓ． 他: 'Ｉｎｄｉｒｕｂｉｎｓ Ｉｎｈｉｂｉｔ Ｇｌｙｃｏｇｅｎ Ｓｙｎｔｈａｓｅ Ｋｉｎａｓｅ-３ｂｅｔａ ａｎｄ ＣＤＫ５／Ｐ２５， Ｔｗｏ Ｐｒｏｔｅｉｎ Ｋｉｎａｓｅｓ Ｉｎｖｏｌｖｅｄ ｉｎ Ａｂｎｏ' Ｊ． ＢＩＯＬ． ＣＨＥＭ． ｖｏｌ． ２７６， ｎｏ． １, 2001, ２５１-２６０頁
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka