疼痛および他の障害の処置のための化合物および方法

Japanese Patent JP2014514259

A

The present invention relates generally to pharmaceutical agents, and in particular, to metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of dual acting MMP-2 and MMP-9 inhibiting compounds that exhibit increased potency, metabolic stability and/or reduced toxicity in relation to currently known MMP-2 and MMP-9 inhibitors for the treatment of pain and other diseases. Additionally, the present invention relates to methods for treating pain, addiction and/or withdrawal symptoms in a patient comprising administering to the patient a pain-reducing effective amount of a present compound.

JPS5817449	[Title of the Invention] Can joker Goubutsuno Seizohou
WO/2002/076921	GALLIC ACID DERIVATIVES AND USE FOR EXPLORING ENDOGENETIC COAGULATION
JPS63503070	[Title of the Invention] Use for increasing crop crop yields of a malonic acid derivative compound

Sacha Reiki, Irving

JP2013556594A

June 19, 2014

March 02, 2011

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Aquilus Pharmaceuticals, Inc.

C07C235/82; A61K31/166; A61K31/192; A61K31/343; A61K31/351; A61K31/38; A61K31/40; A61K31/4035; A61K31/405; A61K31/4166; A61K31/4184; A61K31/45; A61K31/65; A61P1/02; A61P1/04; A61P3/10; A61P7/02; A61P9/00; A61P9/10; A61P9/14; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P19/02; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P25/30; A61P25/32; A61P25/36; A61P27/02; A61P27/16; A61P29/00; A61P31/04; A61P31/12; A61P31/18; A61P35/00; A61P37/08; A61P43/00; C07C237/26; C07C259/06; C07C317/44; C07C323/56; C07D409/12

Hidesaku Yamamoto
Natsuki Morishita

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