Title:
インターロイキン-1βプロテアーゼを阻害する化合物
Document Type and Number:
Japanese Patent JP4113201
Kind Code:
B2
Abstract:
Disclosed are compounds, compositions and methods for inhibiting interleukin-1 beta protease activity, the compounds having the formula (I) wherein R1 is an acyl group, as defined herein, A is an amino acid group as defined herein, n is 0-4 and Y is
Inventors:
Roland E. Doll
Irennegbe K.O.Osifo
Stanley Jay Schmid
Denton W. Heuer
Tina Morgan Ross
Prasad Buoy. Chatterbudura
Catherine P. Protty
Mohammed M.A.Awad
Joseph M. Salbino
James M. Linker
Eric P. Lodge
Jasber Shin
Mark A. Eater
Irennegbe K.O.Osifo
Stanley Jay Schmid
Denton W. Heuer
Tina Morgan Ross
Prasad Buoy. Chatterbudura
Catherine P. Protty
Mohammed M.A.Awad
Joseph M. Salbino
James M. Linker
Eric P. Lodge
Jasber Shin
Mark A. Eater
Application Number:
JP2005121492A
Publication Date:
July 09, 2008
Filing Date:
April 19, 2005
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K31/17; A61K31/165; A61K31/215; C07C229/18; A61K31/235; A61K31/24; A61K31/27; A61K31/34; A61K31/341; A61K31/365; A61K31/38; A61K31/381; A61K31/4172; A61K31/445; A61K31/47; A61K31/472; A61K31/535; A61K31/5375; A61K31/54; A61K38/00; A61K38/55; A61P1/00; A61P1/16; A61P11/00; A61P15/00; A61P19/00; A61P19/02; A61P25/00; A61P27/16; A61P29/00; A61P31/04; A61P35/00; A61P37/00; A61P37/06; A61P43/00; C07C229/22; C07C233/51; C07C235/12; C07C237/08; C07C237/22; C07C237/36; C07C271/22; C07C275/16; C07C311/16; C07C311/19; C07C311/49; C07D209/42; C07D209/44; C07D211/60; C07D215/48; C07D217/26; C07D223/06; C07D233/54; C07D233/64; C07D233/70; C07D233/88; C07D295/08; C07D295/092; C07D295/22; C07D295/30; C07D307/33; C07D307/68; C07D333/24; C07D333/36; C07D333/38; C07D453/02; C07K5/04; C07K5/06; C07K5/08; C07K14/81; C12N9/99
Domestic Patent References:
| JP7500828A | ||||
| JP7504194A | ||||
| JP6340691A |
Attorney, Agent or Firm:
Takashi Ishida
Yoshio Yoshio
Masaya Nishiyama
Higuchi Souji
Yoshio Yoshio
Masaya Nishiyama
Higuchi Souji