Title:
S1P受容体結合能を有する化合物およびその用途
Document Type and Number:
Japanese Patent JP5397461
Kind Code:
B2
Abstract:
Provided are: a compound represented by formula (I):
(wherein ring A and ring D each represent a cyclic group which may have a substituent(s); E and G each represent a bond or a spacer having 1 to 8 atoms in its main chain; L represents a hydrogen atom or a substituent; X represents amino which may have a substituent(s), or a heterocylcic group which contains at least one nitrogen atom and which may have a substituent(s); n represents 0 to 3, in which when n is 2 or more, a plurality of ring A's may be the same or different from one another); a salt thereof; an N-oxide form thereof; a solvate thereof; a prodrug thereof; and a medicament which includes those. The compound represented by formula (I) is capable of binding S1P receptors (in particular, EDG-1 and/or EDG-6), and useful for preventing and/or treating rejection in transplantation, autoimmune diseases, allergic diseases, etc.
Inventors:
Hiroshi Width
Makoto Nakaide
Makoto Nakaide
Application Number:
JP2011286064A
Publication Date:
January 22, 2014
Filing Date:
December 27, 2011
Export Citation:
Assignee:
Ono Pharmaceutical Co., Ltd.
International Classes:
C07C217/58; A61K31/137; A61K31/155; A61K31/165; A61K31/166; A61K31/167; A61K31/18; A61K31/197; A61K31/27; A61K31/275; A61K31/277; A61K31/341; A61K31/343; A61K31/36; A61K31/381; A61K31/395; A61K31/397; A61K31/40; A61K31/401; A61K31/4025; A61K31/404; A61K31/407; A61K31/417; A61K31/42; A61K31/421; A61K31/4245; A61K31/426; A61K31/438; A61K31/44; A61K31/4409; A61K31/445; A61K31/4453; A61K31/47; A61K31/472; A61K31/495; A61K31/496; A61K31/506; A61K31/5375; A61K31/54; A61K31/55; A61K31/551; A61K45/00; A61P1/04; A61P1/16; A61P3/10; A61P9/00; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07C255/58; C07C259/14; C07C311/51; C07C323/32; C07D205/04; C07D207/08; C07D207/09; C07D207/12; C07D207/14; C07D207/16; C07D207/333; C07D209/40; C07D211/10; C07D211/46; C07D211/60; C07D211/70; C07D213/36; C07D213/71; C07D213/74; C07D213/85; C07D215/12; C07D215/18; C07D217/04; C07D233/64; C07D239/42; C07D241/04; C07D241/24; C07D261/10; C07D265/30; C07D271/06; C07D277/04; C07D277/28; C07D295/08; C07D295/10; C07D295/18; C07D307/00; C07D307/38; C07D317/58; C07D333/20; C07D333/34; C07D333/58; C07D413/12; C07D487/08; C07D491/113
Domestic Patent References:
| JP11080107A | ||||
| JP63162672A | ||||
| JP2002531553A | ||||
| JP11080098A | ||||
| JP52133993A |
Foreign References:
| WO2002092068A1 | ||||
| WO2006001463A1 | ||||
| WO2003055521A1 | ||||
| WO1990007494A1 |
Other References:
Thomas A. Ranoほか,SOLID PHASE SYNTHESIS OF ARYL ETHERS VIA THEMITSUNOBU REACTION,Tetrahedron Letters,1995年,Vol. 36, No. 22,pp. 3789-3792
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Kazumi Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Kazumi Nakamura