Title:
抗炎症および免疫抑制活性を有する化合物
Document Type and Number:
Japanese Patent JP4108127
Kind Code:
B2
Abstract:
Amide compounds of formula (I) are new. R' = H or 1-4C alkyl; A = adamantyl or a mono-, bi-or tri-cyclic radial optionally partially or totally unsaturated, which can contain one or more heteroatoms selected from N,S and O and optionally substituted by OH, alkanoyloxy, primary, secondary or tertiary amino, 1-4C amino alkyl, mono-or di- (1-4C alkyl) amino (1-4C alkyl) halogen, 1-4C alkyl or ti (1-4C alkyl) ammonium (1-4C alkyl); Z = a 1-5C carbon chain optionally containing a double bond or an NR' group; R = H or phenyl; X = O or NR' or is absent; r, m =0-2; B = phenylene or cyclohexylene; Y = OH or amino (1-4C alkyl) optionally interrupted by O; with the proviso that A is fluorenyl only when at the same X is not O and Y is not OH, unless the fluorenyl group is substituted by a tri (1-4C alkyl) ammonium (1-4C alkyl) group.
Inventors:
Bertolini, Giorgio
Buffy, Mauro
Leoni, Flavio
Mizurai, Jack
Pavich, Gianfranco
Mascarni, Paolo
Buffy, Mauro
Leoni, Flavio
Mizurai, Jack
Pavich, Gianfranco
Mascarni, Paolo
Application Number:
JP54050597A
Publication Date:
June 25, 2008
Filing Date:
May 12, 1997
Export Citation:
Assignee:
Ital Pharmaco .Societa .Per .Athini
International Classes:
C07C259/10; A61K31/00; C07D217/02; A61K31/16; A61K31/17; A61K31/27; A61K31/47; A61K31/472; A61P29/00; A61P37/00; A61P37/06; A61P43/00; C07C243/24; C07C243/38; C07C259/06; C07C259/08; C07C271/22; C07C271/28; C07C271/38; C07C271/58; C07C275/42; C07D217/04; C07D217/16; C07D217/24
Domestic Patent References:
| JP52014747A |
Other References:
Egyptian Journal of Chemistry, 1980年, Vol.21, No.2, p.115-131
Attorney, Agent or Firm:
Aoyama Aoi
Kyousei Tamura
Kyousei Tamura
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