Title:
炎症の治療においてCXCR2阻害剤として使用される縮合二環式カルボキサミド誘導体
Document Type and Number:
Japanese Patent JP5123667
Kind Code:
B2
Abstract:
The invention relates to compounds of the formula I
in which R1, R2, X, A, B, D and Y1 to Y4 have the meanings indicated in the claims, and the pharmaceutically acceptable salts thereof. Because of their properties as inhibitors of chemokine receptors, especially as CXCR2 inhibitors, the compounds of the formula I and the pharmaceutically acceptable salts thereof are suitable for the prevention and treatment of chemokine mediated diseases such as inflammation.
Inventors:
Stephanie Kneipps
Ürgen dedio
Holger Haiti
Werngart Chehitsky
Sven Gruneberg
Stephen Sims Hock
Raymond Doublet Cosley
Carolina Lanter
Huway Lee
Rosie Share
Alexandra wickel
Ürgen dedio
Holger Haiti
Werngart Chehitsky
Sven Gruneberg
Stephen Sims Hock
Raymond Doublet Cosley
Carolina Lanter
Huway Lee
Rosie Share
Alexandra wickel
Application Number:
JP2007548720A
Publication Date:
January 23, 2013
Filing Date:
December 17, 2005
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
C07C233/83; A61K31/198; A61K31/341; A61K31/351; A61K31/357; A61K31/36; A61K31/381; A61K31/40; A61K31/407; A61K31/415; A61K31/4184; A61K31/4192; A61K31/4196; A61K31/42; A61K31/421; A61K31/423; A61K31/4245; A61K31/426; A61K31/427; A61K31/428; A61K31/433; A61K31/4365; A61K31/44; A61K31/4439; A61K31/445; A61K31/47; A61K31/4709; A61K31/505; A61K31/506; A61P1/02; A61P1/04; A61P1/14; A61P1/18; A61P3/00; A61P7/00; A61P7/02; A61P7/04; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P11/08; A61P11/14; A61P11/16; A61P13/12; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/10; A61P19/02; A61P19/04; A61P19/06; A61P19/10; A61P21/00; A61P25/00; A61P25/06; A61P25/28; A61P27/02; A61P29/00; A61P31/04; A61P31/12; A61P31/14; A61P31/18; A61P31/22; A61P33/06; A61P35/00; A61P35/02; A61P37/06; A61P37/08; A61P39/02; A61P43/00; C07C235/66; C07C237/48; C07C313/16; C07C317/22; C07C323/19; C07C323/59; C07D207/325; C07D211/22; C07D213/30; C07D213/63; C07D215/14; C07D231/12; C07D235/12; C07D239/26; C07D239/38; C07D249/06; C07D249/08; C07D249/18; C07D261/08; C07D263/32; C07D263/56; C07D271/08; C07D277/24; C07D277/64; C07D285/12; C07D307/42; C07D309/06; C07D317/54; C07D319/20; C07D333/56; C07D333/70; C07D401/12; C07D409/04; C07D409/12; C07D413/04; C07D417/04; C07D417/12; C07D487/04; C07D495/04
Foreign References:
| WO2003106402A1 | ||||
| WO2003011862A1 | ||||
| US20020123522 | ||||
| WO1999007351A2 | ||||
| WO2004108681A1 |
Other References:
BOSCHELLI D H,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,1995年,V38,P4597-4614
Journal of Chromatography A,2002年,Vol. 945,45-63
Journal of Chromatography A,2002年,Vol. 945,45-63
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Noriyuki Takebayashi
Junji Yuda
Shoji Miwa
Noriyuki Takebayashi