Title:
ＴＮＦ活性のモジュレーターとしての縮合イミダゾール及びピラゾール誘導体
Document Type and Number:
Japanese Patent JP6495285
Kind Code:
B2
Abstract:
A series of substituted benzimidazole, imidazo[1,2-α]pyridine and pyrazolo[1,5-α]pyridine derivatives, and analogs thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
Inventors:
Brown, Julian Alistair
Carmiano, Mark Daniel
Jones, Elizabeth Pearl
Croprian, Boris
Leverson, James Thomas
Selby, Matthew Duncan
Shaw, Michael Alan
Chu, Chaonin
Carmiano, Mark Daniel
Jones, Elizabeth Pearl
Croprian, Boris
Leverson, James Thomas
Selby, Matthew Duncan
Shaw, Michael Alan
Chu, Chaonin
Application Number:
JP2016537536A
Publication Date:
April 03, 2019
Filing Date:
December 08, 2014
Export Citation:
Assignee:
UCB Biopharma SPR L
International Classes:
C07D471/04; A61K31/444; A61K31/496; A61K31/506; A61K31/5377; A61K31/551; A61K45/00; A61P3/00; A61P9/00; A61P25/00; A61P25/04; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/06; A61P43/00
Domestic Patent References:
| JP63179871A |
Other References:
中井義博 他,3-アリールフタリド誘導体の合成とその可視吸収スペクトル,色材,1900年,63(8),PP.463-469
You, Hanyun et al.,Synthesis of 3-(1H-benzo[d]imidazol-1-yl)isoindolin-1-one derivatives promoted by EtOH-AcOH solvent system,Tetrahedron Letters,2013年,54(23),PP.2972-2975
Shi, Guang et al.,2-[1-(3-Oxo-1,3-dihydro-2-benzofuran-1-yl)-1H-benzimidazol-2-yl]benzoic acid methanol solvate,Acta Crystallographica, Section E: Structure Reports Online,2010年,66(8),o2034
Pan, Shiguang et al.,Iron-Catalyzed N-Alkylation of Azoles via Oxidation of C-H Bond Adjacent to an Oxygen Atom,Organic Letters,2010年,12(9),PP.1932-1935
Liu, Zhao-Peng et al.,Synthesis of novel nucleoside analogues based on 1,3-dihydrobenzo[c]furan core,Chinese Journal of Chemistry ,2006年,24(4),PP.504-508
Karpeiskii, A. M. et al.,Pyridoxal analogs of nucleosides,Bioorganicheskaya Khimiya,1987年,13(8),PP.1059-1065
You, Hanyun et al.,Synthesis of 3-(1H-benzo[d]imidazol-1-yl)isoindolin-1-one derivatives promoted by EtOH-AcOH solvent system,Tetrahedron Letters,2013年,54(23),PP.2972-2975
Shi, Guang et al.,2-[1-(3-Oxo-1,3-dihydro-2-benzofuran-1-yl)-1H-benzimidazol-2-yl]benzoic acid methanol solvate,Acta Crystallographica, Section E: Structure Reports Online,2010年,66(8),o2034
Pan, Shiguang et al.,Iron-Catalyzed N-Alkylation of Azoles via Oxidation of C-H Bond Adjacent to an Oxygen Atom,Organic Letters,2010年,12(9),PP.1932-1935
Liu, Zhao-Peng et al.,Synthesis of novel nucleoside analogues based on 1,3-dihydrobenzo[c]furan core,Chinese Journal of Chemistry ,2006年,24(4),PP.504-508
Karpeiskii, A. M. et al.,Pyridoxal analogs of nucleosides,Bioorganicheskaya Khimiya,1987年,13(8),PP.1059-1065
Attorney, Agent or Firm:
Asamura patent office