To obtain the subject new condensed imidazopyridine derivative having a low density lipoprotein receptor-increasing action and a blood lipid and saccharide- lowering action and useful as an agent for preventing and treating arteriosclerosis and diabetic complications, a hypoglycemic agent, etc.
A new condensed imidazopyrimidine derivative (salt) represented by formula I [the Q ring is a (substituted) pyridine ring; one of R0, R1, R2 is a group of the formula: Y0-Z0 (Y0 is a binding bond, a divalent hydrocarbon group which may be substituted; Z0 is O, N, CO, CS, etc.), and the other two groups are each H, a halogen, a (substituted) hydroxyl group, a (substituted) hydrocarbon group, an acyl; the dotted line portion is a single bond or a double bond]. The derivative of formula I is useful as a low density lipoprotein receptor-increasing agent, a blood lipid-lowering agent, a hypoglycemic agent, an agent for preventing and treating arteriosclerosis and diabetic complications, etc. The compound is obtained by reacting a compound of formula II (Y is a binding bond, CH=CH, etc.) with a compound of formula III [R3, R4 are each H, a (substituted) hydrocarbon group; A, B are each a (substituted) divalent hydrocarbon group; R is a (substituted) hydrocarbon group; X is a binding bond, O, S, etc.].
SHIBOUTA YUMIKO
SUGIYAMA YASUO
KAWAMOTO TETSUJI
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