Title:
条件的に不死化された長期幹細胞ならびにそのような細胞を作製する方法および使用する方法。
Document Type and Number:
Japanese Patent JP7078673
Kind Code:
B2
Abstract:
Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (AML) and cells and methods related to such mouse model are also described.
Inventors:
Cambia, John
Rifaeli, Joseph
Sara, johnson
Turner, Brian Curtis
Rifaeli, Joseph
Sara, johnson
Turner, Brian Curtis
Application Number:
JP2020119082A
Publication Date:
May 31, 2022
Filing Date:
July 10, 2020
Export Citation:
Assignee:
National Jewish Health)
THE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate
THE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate
International Classes:
C12N5/074; A61K35/12; A61K35/28; A61K35/34; A61K35/51; A61K35/545; A61K35/76; A61K48/00; A61L27/36; A61L27/38; A61L27/60; A61P7/06; A61P35/00; A61P35/02; A61P37/02; A61P37/04; A61P37/06; A61P43/00; C07K14/155; C07K14/47; C07K14/50; C07K14/535; C07K14/54; C07K14/65; C07K14/82; C07K19/00; C12N5/0735; C12N5/0775; C12N5/0789; C12N5/0797; C12N5/09; C12N15/09; C12N15/11; C12N15/12; C12N15/63; C12N15/86; C12N15/861; C12N15/863; C12N15/864; C12N15/867; C12Q1/02; G01N33/15; G01N33/50
Domestic Patent References:
| JP2005232148A | ||||
| JP2002541786A | ||||
| JP2005523012A | ||||
| JP2003513672A |
Other References:
Trends Cell Biol,2000,10(7),p.290-5
The Journal of Biological Chemistry,2004年,Vol.279, No.24,p.24986-24993
Nature Medicine,日本,2003年,Vol. 9, No. 11,p. 1428-1432
最新医学,日本,1994年,49巻,6号,1096-1101頁
The Journal of Biological Chemistry,2004年,Vol.279, No.24,p.24986-24993
Nature Medicine,日本,2003年,Vol. 9, No. 11,p. 1428-1432
最新医学,日本,1994年,49巻,6号,1096-1101頁
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto