Title:
CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS
Document Type and Number:
Japanese Patent JP2018100285
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide antidandruff agents that provide improved durability for long lasting effects and are easy and inexpensive to prepare.SOLUTION: The invention provides prodrugs formed by at least one antifungal agent or antibacterial agent and at least one linker and/or carrier. The prodrugs are of (i) (AFA)-X-(L), (ii) [(AFA)-X]-L, (iii) AFA-[X-(L)], or (iv) (AFA)-X, where AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m' is 1 to 10; p is 1 to 10; n' is 1 to 10; and q is 1 to 10, provided that neither of q' and n is 1 and m'' is 1 to 10.SELECTED DRAWING: Figure 22
Inventors:
ABHIJIT S BAPAT
GAUTHAMI MAHESH
RAJESH S GOKHALE
SAYALI S SHAH
SHILADITYA SENGUPTA
SUDHANAND PRASAD
SUMANA GHOSH
SURESH R CHAWRAI
ARORA NIDHI
D SREEDHAR REDDY
MALLIKA MISHRA
KIRTI BAJAJ
GAUTHAMI MAHESH
RAJESH S GOKHALE
SAYALI S SHAH
SHILADITYA SENGUPTA
SUDHANAND PRASAD
SUMANA GHOSH
SURESH R CHAWRAI
ARORA NIDHI
D SREEDHAR REDDY
MALLIKA MISHRA
KIRTI BAJAJ
Application Number:
JP2018022696A
Publication Date:
June 28, 2018
Filing Date:
February 13, 2018
Export Citation:
Assignee:
VYOME BIOSCIENCES BVT LTD
International Classes:
A61K31/496; A61K8/49; A61K8/60; A61K9/107; A61K9/127; A61K9/14; A61K31/7056; A61K47/06; A61K47/08; A61K47/14; A61K47/16; A61K47/34; A61K47/59; A61P17/00; A61P17/02; A61P17/10; A61P31/04; A61P31/10; A61P43/00; A61Q5/00; A61Q5/02; A61Q5/06; A61Q5/12; A61Q19/00
Domestic Patent References:
| JP2011516613A | 2011-05-26 | |||
| JPH11228548A | 1999-08-24 | |||
| JP2000086655A | 2000-03-28 | |||
| JPH10114758A | 1998-05-06 |
Other References:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 13, no. 2, JPN6016015451, 2003, pages 191 - 196
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 19, JPN6016015450, 2002, pages 2775 - 2780
CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 49, no. 9, JPN6016015452, 2001, pages 1102 - 1109
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 19, JPN6016015450, 2002, pages 2775 - 2780
CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 49, no. 9, JPN6016015452, 2001, pages 1102 - 1109
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto