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Title:
CONJUGATES OF CHOLINESTERASE MOIETY AND POLYMER
Document Type and Number:
Japanese Patent JP2017205120
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods for preparing di-conjugated cholinesterase dimer conjugates.SOLUTION: A method of the invention comprises the steps of: (a) combining a reagent composition comprising a plurality of thiol-selective polymer reagent molecules with a composition comprising a plurality of cholinesterase dimer molecules under a conjugate forming condition; (b) subjecting the conjugate mixture to a reducing condition; (c) separating reduced mono-conjugated cholinesterase monomers from the reduced mixture; and (d) removing the reducing condition from the composition containing the reduced mono-conjugated cholinesterase monomers.SELECTED DRAWING: None

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Inventors:
MARY J BOSSARD
HAROLD ZAPPE
LEE SEOJU
LAL A R FERNANDO
Application Number:
JP2017129184A
Publication Date:
November 24, 2017
Filing Date:
June 30, 2017
Export Citation:
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Assignee:
NEKTAR THERAPEUTICS
International Classes:
C12N9/16; A61K9/08; A61K47/60
Domestic Patent References:
JP2008506704A2008-03-06
Foreign References:
WO2008019036A22008-02-14
WO2006063055A22006-06-15
WO2006137052A22006-12-28
WO2000059926A12000-10-12
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto



 
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