CONJUGATE MOLECULAR COMPOSITION AND PRODUCTION OF DRUG CONJUGATE

Title:

CONJUGATE MOLECULAR COMPOSITION AND PRODUCTION OF DRUG CONJUGATE

Document Type and Number:

Japanese Patent JPS58219150

Kind Code:

A

Abstract:

Biologically active drugs, e.g. catecholamine hormones, are coupled to carrier molecules, e.g. monodisperse peptides to produce conjugate molecules. The conjugate molecules retain biological activity, but the pharmacokinetic, pharmacodynamic and/or potency properties of the drug is modified. The drug is coupled to the carrier via a spacer moiety which not only serves to covalently link the drug to the carrier, but also insulates the biologically active portion of the drug, i.e., the pharmacophore, from degradation during the coupling process. The carrier preferably consists of a monodisperse peptide in which the sequence of amino acid residues is carefully preselected and controlled.

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Inventors:

MAARI GUTSUDOMAN
NIIRU KASUTAGUNORI
KENESU ARAN YAKOBUSON
KENESU ROIDO MERUMON
ROBERUTO PEDORO ROOZENKURANTSU
MAIKERU SUTEFUAN BERURANDAA

Application Number:

JP8597983A

Publication Date:

December 20, 1983

Filing Date:

May 18, 1983

Export Citation:

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Assignee:

UNIV CALIFORNIA

International Classes:

A61K31/135; A61K31/19; A61K38/00; A61K47/48; A61P9/04; A61P25/02; C07K1/113; C07K5/065; C07K5/093; C07K14/00; C07K16/00; C07K17/02; C12Q1/04; (IPC1-7): A61K31/135; A61K31/405; A61K31/415; A61K31/557; A61K37/02; C07C103/52; C07G7/00; C12Q1/04

Attorney, Agent or Firm:

Akihide Sugimura

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