Title:
全細胞蓄積を高めるコンジュゲート
Document Type and Number:
Japanese Patent JP7126956
Kind Code:
B2
Abstract:
The present description relates to a conjugated compound comprising cholic acid (ChAc) or a variant thereof, the ChAc conjugated to a non-cell penetrating peptide comprising a nuclear localization sequence (NLS) conjugated to a compound of interest.
Inventors:
Board inn, simon
Leighton, Jeffrey Victor
Leighton, Jeffrey Victor
Application Number:
JP2018568469A
Publication Date:
August 29, 2022
Filing Date:
March 15, 2017
Export Citation:
Assignee:
Defense Therapeutics Inc.
International Classes:
A61K47/68; A61K39/395; A61K45/00; A61K47/54; A61K47/64; A61K51/00; A61P35/00; A61P35/02
Other References:
J. Nucl. Med. (2011), 52, p.1465-1473
Bioconjugate Chem. (1997), 8, p.520-525
Bioconjugate Chem. (2012), 23, p.1091-1104
Bioorganic & medicinal chemistry letters (1994), 4(8), p.1053-1060
Mol. Pharmaceutics (2016 Apr.), 13(6), p.1915-1926
Bioconjugate Chem. (1997), 8, p.520-525
Bioconjugate Chem. (2012), 23, p.1091-1104
Bioorganic & medicinal chemistry letters (1994), 4(8), p.1053-1060
Mol. Pharmaceutics (2016 Apr.), 13(6), p.1915-1926
Attorney, Agent or Firm:
Osamu Yamamoto
Toru Miyamae
Takuji Terachi
Toru Miyamae
Takuji Terachi
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