Title:
ペプチド構造のライブラリーの構築およびスクリーニング方法
Document Type and Number:
Japanese Patent JP5576610
Kind Code:
B2
Abstract:
The present invention provides the means for producing libraries of peptide structures for drug screening applications that are capable of folding or assuming their native conformations independently of artificial scaffolds or flanking sequences in the proteins from which they are derived. The libraries can be highly diverse such that they are representative of the repertoire of protein structures existing in nature. The libraries can also be non-redundant or normalized such that the bias towards specific structures existing in source data sets and/or in nature is/are removed. In a particularly preferred embodiment, the present invention provides 30,000 independent fold structures produced by this method. The present invention also provides computer-readable media and systems comprising structural data in relation to the peptide libraries, and methods for displaying and screening the libraries.
More Like This:
Inventors:
Watt, a pole
Dan Black, Roland
Dan Black, Roland
Application Number:
JP2008555282A
Publication Date:
August 20, 2014
Filing Date:
February 07, 2007
Export Citation:
Assignee:
フィロジカ Limited
International Classes:
C07K1/06; G06F17/30; G06F19/16; C12N15/09; C12P21/02
Attorney, Agent or Firm:
Yusuke Hiraki
Setsu Fujita
Setsu Fujita