Title:
卵巣過剰刺激の制御方法及び当該方法に利用する医薬キット
Document Type and Number:
Japanese Patent JP2005530818
Kind Code:
A
Abstract:
One aspect of the present invention is concerned with a method of controlled ovarian hyperstimulation in a mammalian female, said method comprising the co-administration to said female of —a substance having follicle stimulating hormone activity (FSH substance) in an amount effective to stimulate multiple follicular development; —gonadotropin releasing hormone (GnRH) antagonist in an amount equivalent to a daily subcutaneous dose of at least 0.5 mg ganirelix to prevent a premature LH-surge; and —a LH substance in an amount effective to prevent or suppress symptoms of luteinising hormone (LH) deficiency resulting from the administration of the GnRH antagonist; followed by administering a meiosis and luteinisation inducing substance (ML substance) in an amount effective to stimulate resumption of meiosis and luteinisation, and wherein the LH substance is not obtained from the urine of human females. Another aspect of the to invention relates to a pharmaceutical kit for use in a method of controlled hyperstimulation, which kit comprises: —at least one parenteral or oral dosage unit containing one or more FSH substances in an amount equivalent to a subcutaneous dose of 50-1500 I.U. FSH; —at least one parenteral dosage unit containing one or more GnRH antagonists in an amount equivalent to a subcutaneous dose of 0.5-25 mg ganirelix; —at least one parenteral dosage unit containing one or more LH substances in an amount equivalent to a subcutaneous dose of 50-3000 I.U. recombinant LH; wherein the LH substance is not obtained from the urine of human females.
Inventors:
Bunshoten, Efeld Johannes
Koelling Bennink, Hermann Yang Temen
Koelling Bennink, Hermann Yang Temen
Application Number:
JP2004510888A
Publication Date:
October 13, 2005
Filing Date:
June 06, 2003
Export Citation:
Assignee:
Ares Trading Society Anonym
International Classes:
A61K38/04; A61K38/09; A61K38/24; A61P15/08; A61K45/06; (IPC1-7): A61K45/06; A61K38/04; A61K38/24; A61P15/08
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama