Title:
制御放出組成物
Document Type and Number:
Japanese Patent JP2005532387
Kind Code:
A
Abstract:
An improved composition for controlling the release profile of an active compound through the intestinal tract comprises particles, especially pellets, containing the active compound, which are coated with a pH dissolution dependent coating material or a polymethacrylate material, which is preferably pH dissolution dependent, to a certain thickness depending upon the location and rate of release of the active compound that is desired. In preferred compositions, two or more pluralities of particles, in which particles of each plurality are coated with pH dissolution dependent coating material or polymethacrylate material to a different thickness to those of each other plurality, are contained within an enterically coated capsule and provide release of the active compound at various desired locations in the intestinal tract.
Inventors:
Spiers, Christopher Jay
Moir, Peter
Williams, Richard
Clark, Michael
Moir, Peter
Williams, Richard
Clark, Michael
Application Number:
JP2004518982A
Publication Date:
October 27, 2005
Filing Date:
July 04, 2003
Export Citation:
Assignee:
TEMREL INC.
International Classes:
A61K9/48; A61K9/50; A61K9/58; A61K31/167; A61K31/4164; A61K31/573; A61K38/46; A61K47/32; (IPC1-7): A61K31/573; A61K9/48; A61K9/58; A61K31/167; A61K31/4164; A61K38/46; A61K47/32
Domestic Patent References:
| JP2002504108A | 2002-02-05 | |||
| JPH1067657A | 1998-03-10 |
Foreign References:
| US5834024A | 1998-11-10 |
Attorney, Agent or Firm:
Taku Takeuchi
Shoji Okamoto
Shoji Okamoto