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Title:
CONTROLLED-RELEASE NANOPARTICULATE COMPOSITIONS
Document Type and Number:
Japanese Patent JP2015131864
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide controlled release nanoparticulate compositions comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration.SOLUTION: A controlled release nanoparticulate composition comprises (a) a poorly soluble agent to be administered having an effective average particle size of less than about 1000 nm; (b) at least one surface stabilizer associated with the surface of the agent, and (c) at least one pharmaceutically acceptable rate-controlling polymer. The composition provides controlled release of the agent for a time period ranging from about 2 to about 24 hours or longer.

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Inventors:
SWANSON JON
JAIN RAJEEV A
HONTZ ROBERT
DEVANE JOHN G
CUMMING KENNETH IAIN
CLANCY MAURICE JOSEPH ANTHONY
CODD JANET ELIZABETH
Application Number:
JP2015089173A
Publication Date:
July 23, 2015
Filing Date:
April 24, 2015
Export Citation:
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Assignee:
ELAN PHARMA INT LTD
International Classes:
A61K45/00; A61K9/14; A61K9/16; A61K9/20; A61K9/22; A61K9/26; A61K9/30; A61K9/32; A61K9/52; A61K31/192; A61K47/12; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/42; A61P29/00
Domestic Patent References:
JP2001509518A2001-07-24
JPH08501073A1996-02-06
JPH04295420A1992-10-20
JPH07196534A1995-08-01
JP2001524950A2001-12-04
JP2001507359A2001-06-05
JPH03206030A1991-09-09
Foreign References:
WO1998035666A11998-08-20
WO1998041194A11998-09-24
WO1998029095A21998-07-09
Attorney, Agent or Firm:
Hatsushi Shimizu
Toshi Gobe
Koichi Niimi
Ryuichi Inoue
Tomohiko Kobayashi
Masato Ozeki



 
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