Title:
銅含有アミン・オキシダーゼの炭素環ヒドラジノ阻害剤
Document Type and Number:
Japanese Patent JP4377221
Kind Code:
B2
Abstract:
The present invention is directed to carbocyclic hydrazino compounds that function as inhibitors of copper-containing amine oxidases commonly known as semicarbazide-sensitive amine oxidases (SSAO), including the human SSAO known as Vascular Adhesion Protein-I (VAP-1). These SSAO inhibitors have therapeutic utility as drugs to treat conditions and diseases including, but not limited to, a number of inflammatory conditions and diseases (in particular chronic inflammatory conditions such as chronic arthritis, inflammatory bowel diseases, and chronic skin dermatoses), diseases related to carbohydrate metabolism and to aberrations in adipocyte differentiation or function and smooth muscle cell function, and vascular diseases. The novel compounds have the general formula: or a pharmaceutically acceptable solvate, hydrate, or salt thereof wherein R1 to R11 are as defined herein.
Inventors:
Smith, david john
Fureep, Ferenc
Pyrabist Maruyo
Lazar, Larslaw
Aralanta, Sakari
Bainio, Petri
Sakonui, Jolt
Fureep, Ferenc
Pyrabist Maruyo
Lazar, Larslaw
Aralanta, Sakari
Bainio, Petri
Sakonui, Jolt
Application Number:
JP2003511809A
Publication Date:
December 02, 2009
Filing Date:
July 11, 2002
Export Citation:
Assignee:
BIOTY THERAPIES CORPORATION
International Classes:
C07C243/20; A61K31/15; C12N9/99; A61P1/04; A61P3/06; A61P3/08; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/02; A61P17/06; A61P19/02; A61P19/04; A61P25/00; A61P25/02; A61P25/28; A61P29/00; A61P37/00; C07C241/02; C07D273/00
Foreign References:
| WO1998055447A1 |
Other References:
Journal of Organic Chemistry,1970年,Vol.35, No.4,p.1149-p.1154
Journal of Organic Chemistry,1970年,Vol.35, No.4,p.1155-p.1165
Liebigs Annalen der Chemie,1992年,No.3,p.273-p.278
Journal of Organic Chemistry,1970年,Vol.35, No.4,p.1155-p.1165
Liebigs Annalen der Chemie,1992年,No.3,p.273-p.278
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Masaya Nishiyama