Title:
CORTICOSTEROID ANTIIINFLAMMATRY DRUG
Document Type and Number:
Japanese Patent JPS54132563
Kind Code:
A
Abstract:
Corticosteroids of the formulae
wherein:
R<1><6> is methyl; and
R<1><7> independently is hydrogen, or C2 to C6 linear or branched acyl or R<1><6> and OR<1><7> taken together are the radical (IV)
where R<3> is hydrogen, C1 to C6 linear or branched alkyl, and R<4> is the same or different than R<3> as defined above or is C1 to C6 linear or branched alkoxy or R<3> and R<4> taken together with the carbon atom of said radical is C4 to C9 heterocyclic alkyl having one heterocyclic atom that is oxygen, R<2><1> independently is C1 to C6 linear or branched alkyl or C4 to C9 heterocyclic alkyl having one heterocyclic atom that is oxygen; or OR<1><7> and OR<2><1> taken together are the radical (IV) where R<3> is defined above and R<4> is C1 to C6 linear or branched alkoxy; Y is selected from the group methyl, halomethyl, and the radical -CH2OC(O)R where R is C2 to C6 linear or branched alkyl; Z independently is C1 to C7 linear or branched acyloxy, hydroxy or halo or Z and OR<1><7> taken together are the radical (IV) where R<3> and R<4> is defined above; are useful as anti-inflammatory agents. Compounds III can be prepared from compounds I through compounds II.
Inventors:
MAIKERU MAAKUSU
DENISU JIEI KAATESUZU
DENISU JIEI KAATESUZU
Application Number:
JP4041579A
Publication Date:
October 15, 1979
Filing Date:
April 05, 1979
Export Citation:
Assignee:
SYNTEX INC
International Classes:
A61K31/573; A61K31/575; A61K31/58; A61P29/00; C07J5/00; C07J9/00; C07J21/00; C07J71/00; (IPC1-7): A61K31/575; A61K31/58; C07J9/00; C07J71/00