Title:
CREATINE PRODRUGS, COMPOSITIONS THEREOF, AND METHODS OF USE THEREOF
Document Type and Number:
Japanese Patent JP2022078213
Kind Code:
A
Abstract:
To provide membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering the creatine prodrugs or pharmaceutical compositions thereof.SOLUTION: The invention provides compounds of formula (III) or 6-membered ring derivatives thereof, and pharmaceutically acceptable salts, solvates, tautomers or stereoisomers thereof.SELECTED DRAWING: None
Inventors:
WILLIAM F BRUBAKER
Application Number:
JP2022033882A
Publication Date:
May 24, 2022
Filing Date:
March 04, 2022
Export Citation:
Assignee:
FARMINGTON PHARMA DEV
International Classes:
C07D271/06; A61K31/4245; A61K31/5395; A61P9/00; A61P9/10; A61P21/00; A61P25/00; A61P25/18; C07D273/04; C07D413/12
Domestic Patent References:
| JP7037597B2 | 2022-03-16 | |||
| JP2014527969A | 2014-10-23 |
Foreign References:
| US20080051371A1 | 2008-02-28 | |||
| WO2014018570A1 | 2014-01-30 | |||
| WO2009143630A1 | 2009-12-03 | |||
| WO2010005692A2 | 2010-01-14 |
Attorney, Agent or Firm:
Hiroki Masaki
Yusaku Tokai
Horiuchi Makoto
Masako Yamauchi
Shuichi Sonomoto
Yusaku Tokai
Horiuchi Makoto
Masako Yamauchi
Shuichi Sonomoto
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