CRISPR-BASED COMPOSITIONS AND METHODS OF USE

Title:

CRISPR-BASED COMPOSITIONS AND METHODS OF USE

Document Type and Number:

Japanese Patent JP2023134670

Kind Code:

A

Abstract:

To provide modified compositions for use in CRISPR systems, and methods of using the same.SOLUTION: Length-modified and chemically modified forms of crRNA and tracrRNA are described for use as a reconstituted guide RNA for interaction with Cas9 of CRISPR systems. The resultant length-modified and chemically modified forms of crRNA and tracrRNA are economical to produce and can be tailored to have unique properties relevant to their biochemical and biological activities in a situation of a CRIPSR Cas9 endonuclease system.SELECTED DRAWING: Figure 10

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Inventors:

MICHAEL ALLEN COLLINGWOOD
ASHLEY MAE JACOBI
GARRETT RICHARD RETTIG
MOLLIE SUE SCHUBERT
MARK AARON BEHLKE

Application Number:

JP2023115668A

Publication Date:

September 27, 2023

Filing Date:

July 14, 2023

Export Citation:

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Assignee:

INTEGRATED DNA TECH INC

International Classes:

C12N15/11; C12N15/09; C12N15/10

Attorney, Agent or Firm:

Kawaguchi International Patent Office

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