Title:
CRISPR-CAS-RELATED METHODS, COMPOSITIONS, AND COMPONENTS FOR CANCER IMMUNOTHERAPY
Document Type and Number:
Japanese Patent JP2022081522
Kind Code:
A
Abstract:
To provide CRISPR/CAS-related compositions and methods for treating cancer.SOLUTION: Provided is a modified cell, comprising a modification of TRAC or TRBC gene, performed by delivery of a complex comprising a gRNA molecule targeting T cell receptor α (TRAC) or T cell receptor β (TRBC), and S. pyogenes Cas9 polypeptide, the gRNA molecule comprising a targeting domain comprising a sequence that is identical to or less than 3 nucleotides different from the targeting domain sequence selected from a particular sequence.SELECTED DRAWING: None
Inventors:
G GRANT WELSTEAD
ARI E FRIEDLAND
MORGAN L MAEDER
DAVID A BUMCROT
ARI E FRIEDLAND
MORGAN L MAEDER
DAVID A BUMCROT
Application Number:
JP2022026505A
Publication Date:
May 31, 2022
Filing Date:
February 24, 2022
Export Citation:
Assignee:
EDITAS MEDICINE INC
International Classes:
C12N15/09; A61K31/7105; A61K35/17; A61K38/16; A61K38/46; A61P35/00; A61P37/02; C12N5/10
Foreign References:
| WO2014191128A1 | 2014-12-04 |
Attorney, Agent or Firm:
Masahiro Nanjo
Ayako Seta
Koichiro Inami
Hidemitsu Hara
Ayako Seta
Koichiro Inami
Hidemitsu Hara
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