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Title:
徐放性医薬製剤に利用する架橋高アミローススターチとその製造方法
Document Type and Number:
Japanese Patent JP5025066
Kind Code:
B2
Abstract:
The present invention relates to a novel form of cross-linked high amylose starch and processes for its manufacture. Such cross-linked high amylose starch is useful as an excipient in a controlled-release pharmaceutical formulation when compressed with pharmaceutical agent(s) in a tablet. Such cross-linked high amylose starch is prepared by (a) cross-linking and chemical modification of high amylose starch, (b) gelatinization, and (c) drying to obtain a powder of said controlled release excipient. In a preferred embodiment, such cross-linked high amylose starch is prepared in the following steps: (1) granular cross-linking and additional chemical modification (e.g., hydroxypropylation) of high-amylose starch; (2) thermal gelatinization of the starch from step (1); and (3) drying the starch from step (2) to yield a powder capable of being used as a controlled release excipient.

Inventors:
Rennerts, Vincents
Beck, Roland, Helwig, Friedrich
Bogart, ercy, fan
Francois, Tuinard
Hopke, Liner
Deseva Ox, Cyril
Application Number:
JP2002506706A
Publication Date:
September 12, 2012
Filing Date:
June 26, 2001
Export Citation:
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Assignee:
LABOPHARM INC.
International Classes:
A61K47/36; A61K9/20; A61K9/22; A61K31/137; A61K31/167; A61K31/277; A61K31/496; A61K47/12; A61K47/14; A61K47/26; C08B33/00; A61K9/00
Domestic Patent References:
JP9227174A
JP2002504508A
Foreign References:
US5456921
Other References:
Cereal Chemistry,1976年,Vol.53 , No.2,pp.282-290
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita