Title:
徐放性医薬製剤に利用する架橋高アミローススターチとその製造方法
Document Type and Number:
Japanese Patent JP5025066
Kind Code:
B2
Abstract:
The present invention relates to a novel form of cross-linked high amylose starch and processes for its manufacture. Such cross-linked high amylose starch is useful as an excipient in a controlled-release pharmaceutical formulation when compressed with pharmaceutical agent(s) in a tablet. Such cross-linked high amylose starch is prepared by (a) cross-linking and chemical modification of high amylose starch, (b) gelatinization, and (c) drying to obtain a powder of said controlled release excipient. In a preferred embodiment, such cross-linked high amylose starch is prepared in the following steps: (1) granular cross-linking and additional chemical modification (e.g., hydroxypropylation) of high-amylose starch; (2) thermal gelatinization of the starch from step (1); and (3) drying the starch from step (2) to yield a powder capable of being used as a controlled release excipient.
Inventors:
Rennerts, Vincents
Beck, Roland, Helwig, Friedrich
Bogart, ercy, fan
Francois, Tuinard
Hopke, Liner
Deseva Ox, Cyril
Beck, Roland, Helwig, Friedrich
Bogart, ercy, fan
Francois, Tuinard
Hopke, Liner
Deseva Ox, Cyril
Application Number:
JP2002506706A
Publication Date:
September 12, 2012
Filing Date:
June 26, 2001
Export Citation:
Assignee:
LABOPHARM INC.
International Classes:
A61K47/36; A61K9/20; A61K9/22; A61K31/137; A61K31/167; A61K31/277; A61K31/496; A61K47/12; A61K47/14; A61K47/26; C08B33/00; A61K9/00
Domestic Patent References:
| JP9227174A | ||||
| JP2002504508A |
Foreign References:
| US5456921 |
Other References:
Cereal Chemistry,1976年,Vol.53 , No.2,pp.282-290
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita