Title:
ＤＮＡナノ構造体を含む凍結保護用組成物及びその利用方法
Document Type and Number:
Japanese Patent JP7378750
Kind Code:
B2
Abstract:
The present invention relates to a composition for cryopreservation, comprising: a nucleic acid structure which comprises a scaffold nucleic acid folded at predetermined positions to form multiple strands, and a plurality of staple nucleic acids wherein at least a portion of a sequence thereof comprises a complementary sequence to that of the scaffold nucleic acid, which are bound to at least one of the strands of the scaffold nucleic acid to form a double strand; linkers coupled to at least one of single strands in the nucleic acid structure; and an anti-freezing peptide coupled to at least one of the linkers, so as to exhibit excellent freeze-protection effects, which in turn increase cell viability during cryopreservation of cells and tissues, while retaining original texture of food even when used for freezing the food.
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Inventors:
Ann, Dong Jun
Kim, Do Nyuun
Li, Ye Dam
Li, Jang Seok
Kim, Do Nyuun
Li, Ye Dam
Li, Jang Seok
Application Number:
JP2022573705A
Publication Date:
November 14, 2023
Filing Date:
March 12, 2021
Export Citation:
Assignee:
KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION
International Classes:
C12N15/11; A01N1/02; A23L3/37; C07K4/00; C12N1/20
Domestic Patent References:
| JP2017503845A |
Foreign References:
| KR1020180109267A | ||||
| KR1020180084782A | ||||
| KR1020150137440A | ||||
| US6307020 | ||||
| WO1991010361A1 | ||||
| KR1020180109237A |
Other References:
SACCA, B et al.,Orthogonal protein decoration of DNA origami,Angew Chem Int Ed Engl,49(49),2010年12月03日,pp.9378-9383
XIN, Y et al.,Cryopreservation of DNA origami nanostructures,Small,16(13),2020年04月,e1905959
XIN, Y et al.,Cryopreservation of DNA origami nanostructures,Small,16(13),2020年04月,e1905959
Attorney, Agent or Firm:
Takeshi Ebe
Kazuo Asahi
Kazuo Asahi