Title:
１５β－ヒドロキシ－酢酸オサテロンの結晶多形
Document Type and Number:
Japanese Patent JP7210278
Kind Code:
B2
Abstract:
Provided is a crystalline polymorphic form A of 15²-hydroxy-osaterone acetate having an improved stability (storage stability, pulverization stability, and absorption characteristics). In a powder X-ray diffraction spectrum, characteristic diffraction peaks of the crystalline polymorphic form A of 15²-hydroxy-osaterone acetate appear at diffraction angles 2¸ of 9.6° ± 0.2°, 17.1° ± 0.2°, and 20.2° ± 0.2°. The crystalline polymorphic form A has a melting point of 280 to 283°C and is a prism crystal.
Inventors:
Takayoshi Nakagawa
Hiroyuki Hayashi
Koichi Miyazaki
Shigeki Iwashita
Hiroyuki Hayashi
Koichi Miyazaki
Shigeki Iwashita
Application Number:
JP2018517047A
Publication Date:
January 23, 2023
Filing Date:
May 10, 2017
Export Citation:
Assignee:
Aska Pharmaceutical Co., Ltd.
International Classes:
C07J73/00; A61K9/20; A61K31/58; A61P5/28; A61P13/08; A61P17/08; A61P17/14; A61P35/00
Domestic Patent References:
| JP2591640B2 | ||||
| JP6192228A | ||||
| JP4235188A | ||||
| JP61263985A |
Other References:
Chem.Pharm.Bull.,1993,Vol.41,No.5,p.870-875
Organic Process Research & Development,2009,Vol.13,No.6,p.1241-1253
Journal of Pharmaceutical Sciences,1979,Vol.68,No.2,p.175-177
Organic Process Research & Development,2009,Vol.13,No.6,p.1241-1253
Journal of Pharmaceutical Sciences,1979,Vol.68,No.2,p.175-177
Attorney, Agent or Firm:
Hiroshi Sakanaka
Mitsuo Hokita
Mitsuo Hokita
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